DR. BHARAT SUTHARMobile: +91 9833450059 ~ E-Mail: bgsuthar2009@gmail.com

In pursuit of senior position in the field of R&D in pharmaceutical industry

SUMMARY

Ph.D. (Heterocyclic Synthesis)/ M.Sc. (Organic Chemistry) with 16 years of experience across Pharma industry. Scope of excellence entails:- New Drug Discovery - Novel molecule synthesis - SAR development - Scale-up for DMF filling - Technology transfer - Lead identification- Lead optimization - Team building – Team management

Currently associated with Ajanta Pharma Ltd., Mumbai as Sr. Manager Synthetic Development Lab (API R&D) .

Possesses strong acumen in theoretical & practical details of Synthetic Organic Chemistry with a thorough understanding of modern synthetic methods and reaction mechanisms.

Proficient in handling:o New drug discovery and API Process development for Regulatory Authorities like

USFDA.o Project planning and execution, Team building and management.

o Interaction with DRA for IND filling at DCGI and other query response.

o Analysis of problems, conceptualization of potential solutions and implementation of strategies for achieving solutions at lab/ plant level.

Possess research, analytical, problem-solving and team building & management skills. 13 provisional patent filled in US and India for Drug discovery and process development of API’s.

3 International journal paper publication.

SKILL SET

Conversant with synthetic chemistry for new drug discovery and process development. Exposure of new drug discovery for anti-diabetic drugs like (PTP-1B inhibitors, DPP-IV and PPAR-

γ). Daily interaction with Biology, IPR and regulatory department for NCE filling requirement. Day to day work allocation and progress tracking of synthetic group of 20 scientist for process

development of API. Adept in project planning, timeline set up and progress tracking, costing, transformation of

process to commercial scale, process development report. Dexterous in interfacing with cross-functional teams at R&D department and other department

for ensuring better execution of various projects. Possesses IPR and regulatory knowledge with key skills in interacting with Regulatory and IPR

departments for facilitating DMF filing requirements, patent interpretation and landscaping for non infringement action.

CAREER PROGRESSION

Since Nov’2010 Ajanta Pharma Ltd., Mumbai Sr. Manager (API Division) (Advent Research Centre)

Key Highlights:

Heading API synthetic group responsible for development of new API for DCGI NCE filling. Scale-up and documentation required for clinical trials and BE study requirement for DCGI

dossier submission. DMF preparation and Query response to DCGI. Development of cost effective, non infringing scalable chemical processes for different API's and

transfer the technology successfully for supporting production. Co-ordination with regulatory and quality assurance department for proper documentation of API

required for submission to regulatory authorities. Interaction with higher Management for providing regular update regarding progress &

prioritization of projects. Successfully completed development of 3 API for DCGI NCE filling. Technical member in addressing the queries by the regulatory authorities. Leading Team of 20 scientist.

Jun’2007 – Oct’2010 Lupin Ltd., Pune Research Scientist (Lupin Research Park) (Manager)

Key Highlights:

Worked in New Drug Discovery department in synthesis of Anti-diabetic drug. Design of molecule interaction with CADD and synthetic route designs for the lead identification. Molecule library synthesis of anti-diabetic, scale-up of molecule for advance biological study. Regular interaction with CMB and pharmacology department for in-vitro and in-vivo screening

data discussion. Trained and managed junior team members on work planning assignment & work monitoring. Handled day-to-day planning and team management for effective synthesis and routine lab work. Dec’2003 – May’2007 Torrent pharma Ltd., Ahmedabad

Scientist II (Torrent Research Centre)

Key Highlights:

Worked in medicinal chemistry lab for the new drug discovery department. Involve in lead identification to lead optimization of PTP-1B inhibitor active as anti-diabetic. Synthesized number of molecule required for in-vitro and In-vivo testing for SAR development. Regularly interacted with Patents, biology department and Analytical Departments for better

execution of projects.

Apr’2003 – Nov’2003 Wockhardt Ltd., Aurangabad Research Associate

Key Highlights:

Worked in synthetic department of Drug discovery research of antibacterial agent. Participated in lead identification and lead optimization for the oxazolidine class molecule.

Synthesized number of molecule with good in-vitro biological activity. Planning and procurement of reagents and solvents.

Jun’2000 – Mar’2003 Alembic Ltd., Vadodara Junior Scientist

Key Highlights:

Handled process development activities and scaled up API’s and intermediates. Worked on process development of anti diabetic, antiulcer, anti hypertension, anti cholesterol

and erectile disfunctioning agent. Participated in technology transfer from R&D to plant scale during pilot plant scale-up project. Planning and procurement of reagents and solvents.

ACADEMIC CREDENTIALS

Ph.D. (Heterocyclic Synthesis) from Hemchandarcharya North Gujarat University, Gujarat in 2009.

M.Sc. (Organic Chemistry) from Sardar Patel University, Gujarat in 2000. Secured 64%. B.Sc. (Chemistry) from Sardar Patel University, Gujarat in 1998. Secured 63%.

PATENTS AND PUBLICATIONS

1. An Improved Process for preparation of Efonidipine. o Application No. 1586/MUM/2015

2. An Improved Process for preparation of Cilnidipine. o Application No. 196/MUM/2015

3. Process for preparation of Desonide sodium phosphate. o Application No. 3993/MUM/2014

4. Process for preparation of 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine and pharmaceutically acceptable salts thereof. (Teneligliptin)

o Application No. 1996/MUM/2014

5. Process for preparation of polymorphic form II of Febuxostat. o Application No. 820/MUM/2014

6. Process for preparation of Zucapsacino Application No. 3638/MUM/2013

7. Process for preparing Diflupredneto Application No. 2535/MUM/2013

8. An Improved Process for the manufacturing of Roflumilast. o Application No. 1264/MUM/2012

9. An Improved Process for Preparation Ilaprazole. o Application No. 584/MUM/2011

10. Process for the Preparation of Besifloxacin. o Application No. 1159/MUM/2011

11. Thiazolinones and Oxazolinones and their Use as PTP 1B Inhibitors. o Patent No. WO/2007/032028

12. Novel Protein Tyrosine Phosphatase-1B Inhibitors. o Patent No. WO/2009/109999

13. Novel Protein Tyrosine Phosphatase-1B Inhibitors. o Patent No. WO/2009/109998

14. Synthesis, Characterization and Antimicrobial Evaluation of novel 4-pyrrol-1-yl-5, 6, 7, 8–Tetrahydro-Pyrido [4’, 3’:4, 5] Thieno [2, 3-d] Pyrimidine Derivatives. .

o Journal of Hetrocyclic Chemistry, 2009, 46(5), 975-979

15. Synthesis and Biological Activity of Novel 1, 3, 5-Trisubstituted 1, 2, 4-Triazole Derivatives. o Journal of Heterocyclic Chemistry, 2010, 47 (1), 156-161.

16. Synthesis and Antibacterial Evaluation of some Novel 2-Amino-4-Phenyl-Thiazolyl Derivatives. o Bulletin of Korian Chemical Society, 2010, 31(4), 793-797.

PERSONAL DETAILS

Date of Birth : 28th August 1977 Address : 601, B-wing, Shreeji Sea View, Bhayandar East, Thane, Maharshtra-401105