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MACHINERY USED FOR PACKING,LABELLING AND PRINTING FOR DIFFERENT DOSAGE FORMS MENTOR: Prof. Dr. R. NAGARAJU M.Pharm.,Ph.D Dept.Of Pharmaceutics PRESENTED BY: P. SRAVANI 2015MPH40017 Dept.Of Pharmaceutics SPMVV - TIRUPATHI

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Page 1: Sravani ppt

MACHINERY USED FOR PACKING,LABELLING AND

PRINTING FOR DIFFERENT DOSAGE FORMS

MENTOR:Prof. Dr. R. NAGARAJU

M.Pharm.,Ph.DDept.Of Pharmaceutics

PRESENTED BY:P. SRAVANI

2015MPH40017Dept.Of Pharmaceutics

SPMVV - TIRUPATHI

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CONTENTS:

• Purpose of packing,Labelling and Printing.• Packing Machinery• Labelling Machinery• Printing Machinery• Conclusion• References

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PURPOSE OF PACKING, LABELLING AND PRINTING

• Containment

• Information transmission

• Physical and barrier protection

• Transport

• Display

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PACKAGING MACHINERY

• Packaging machinery is used to package products or components.

• Packaging machinery includes related machinery for sorting, counting, and

accumulating.

• There are many different types of packaging machinery.

• Common packaging machinery types include: accumulators, batching

machinery, bagging machinery, sleever machinery, box making machinery,

bundling machinery, capping machinery, Cartoning machinery, and closing

machinery

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PACKAGING MACHINERY

o Blister packing machine

o Capsule filling machine

o Ampoule and vial filling machine

o Tube filling machine

o Shrink wrapping machine

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BLISTER PACKAGING MACHINE

• In pharmaceutical industry Blister Packaging Machines are used for the packing

tablets, capsules, pills and other similar products packing.

• The packing process start with the capsules or tablets being loaded into a hopper

and then into a feeder, which in turn can either be linear feeder or a brush box

feeder depending on the shape of the product and also the material to be used.

• Heated rollers in the machine use different plastic films to form blisters that are

subsequently filled with tablets.

• Some machines make use of alluminium foil to form blisters.

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• Machines are manufactured according to the size, depth and material used to form

blisters.

• After tablets have been inserted in the formed blisters, cavities are heat sealed

using foil.

• Blister Sealing Machines are used to seal filled plastic blister to a piece of coated

carton board, by heat.

• The blister is kept in the sealing die which has the same shape as that of the

cavity. The cavities are then filled and sealed by a foil using heat.

• Blister Trimming Machines are used for cutting, trimming the sealed blister or

formed blister packs

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BLISTER PACKING MACHINE

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CAPSULE FILLING MACHINE

• High Speed Automatic Capsule Filling machines are suitable for filling powders

and pellets.

• These are versatile machines with several outstanding features both functional

and mechanical.

• The machines have capabilities to give an output of 40,000 capsules and 90,000

capsules per hour with high filling accuracy and can accommodate capsule sizes.

• Capsule fillers are used to fill hard gelatin and non gelatin capsules with pre

determined quantity of liquids, powders, pellets, tablets.

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• Capsules are normally fed into the machine, the filler then align, opens and

accurately fills each capsule and recloses.

• Fillers generate minimum dust with lowest level of product loss. Non-separated,

double loaded capsules and improperly inserted capsules are automatically

rejected by machines to maintain the consistency in the quality of product.

• Most capsule fillers are characterized with fast changeover time to accommodate

a variety of capsules in terms of shapes and size.

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TYPES OF CAPSULE FILLING MACHINE

Model - A 4040,000 capsules per hour for powder 30,000 capsules per hour for pellets.

Model - A 9090,000 capsules per hour for powder 70,000 capsules per hour for pellets.

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SEMI AUTOMATIC CAPSULE FILLING MACHINE

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AUTOMATIC CAPSULE FILLING MACHINE

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ADVANTAGES:

• High Quality Capsule Filling Machine requires minimal maintenance and easy to

clean.

• Another important feature is the installation of speed adjusting equipment and

automatic counters ensuring the right quantity of capsules being filled and packed.

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AMPOULE FILLING MACHINE

• Ampoule filling machines are completely cover the product in the inert glass and do

not have a rubber stopper or any other material in direct contact with the drug.

• Ampoule filling machines can be used to fill ampoules as well as vials and the speed

varies according to the technology.

• Certain ampoule coding machines apply ring banding to the completed ampoule tips

for accurate identification.

• Filling range of these machines is normally between 1ml to 20 ml.

• Most ampoule fillers are characterized with fast changeover time to accommodate a

variety of ampoules in terms of shapes and size.

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ADVANTAGES:

• High quality Ampoule filling machines require minimal maintenance and are very

easy to clean.

• The installation of speed adjusting equipment and “no ampoule no fill” capability

to ensure that unfilled ampoules are not packed.

• Check weight mechanism of the machine helps to maintain consistency in each

batch.

• Sealing is done either by laser sealing system or conventional gas flame.

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AMPOULE FILLING MACHINE

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LIQUID FILLING MACHINE

• Liquid Filling Machines are specialized machines used to fill bottles, vials,

ampoules and other containers with pre determined quantity of liquids.

• These machines adopt a volumetric piston filling mechanism for smooth

liquid filling.

• These machines are easy to operate and fill precise quantity of liquid into

containers

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TYPES OF LIQUID FILLING MACHINE

• Vaccum liquid filling machine:

It is best suited for filling liquids that are foamy and caustic in nature.

• Automatic liquid filling machine:

Automatic anti-pressure liquid filling machine adopting the ways of

vacuum filling to fill all various of overflow products with high accuracy and versatility

ensure filling without leakage, no foam and damaged bottle is not incorporated.

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• Semi automatic liquid filling machine:

volumetric liquid filling machine works on volumetric principle.

The desired volume can be adjusted.

Bottles are kept bellow the nozzles manually.

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ADVANTAGES:

• Filling equipment allow adjustment of different sized bottles without

changing parts and also have 'No Bottle-no fill' mechanism.

• Most machines meet the GMP norms and are easy to clean and maintain.

• The output of these machines depends whether they are semi or fully

automatic.

• Liquid Filling machines are generally used in Pharmaceutical and chemical

industries

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LIQUID FILLING MACHINE

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TUBE FILLING MACHINE

• Automatic Tube Filling Machines fill ointment/cream in cylindrical alluminium

collapsible/coextruded plastic tubes and close it absolutely safely and symmetrically.

• The empty tubes are first loaded in the cassette, which then travels through the guides

to be held in the feeder by vacuum.

• The tube is then fed into the tube holder by the feeder

• when the tube is lifted, its presence is checked by a sensor and this signal is relayed to

the filling station. Hence if a tube is not there, the dosing action does not take place

and hence there is no fill.

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• If the tube is not ejected out by the ejector, the machine stops in order to avoid

damages.

• In case of any jamming on the indexing system, to avoid breakages, the load is

sensed & the machine stops automatically.

• Blow off device and tail cutting arrangements to avoid the paste / cream touching

the sealing portion of the tube.

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TUBE FILLING MACHINE

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ADVANTAGES:

• Audio visual Alarm Annunciation System for any abnormal conditions of the

machine.

• Comprehensive control panel with all protection features.

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SHRINK WRAPPING MACHINE

• Shrink wrap machines make use of plastic to effectively seal a container or

product by tightly surrounding it.

• Vacuum shrink wrapping can prevent bacteria form entering the product and

also protect them form wear and tear during transportation.

• The process involves tightening a thermoplastic film around the product and

shrinking it by heat.

• It also helps to add strength to the stack, making it dust, water and tamper

proof.

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ADVANTAGES:• L-Bar sealers are used to pack products with the help of electricity rather than heat.

Heat guns are used to wrap blister packs.

• Vacuum sealers are used to shrink wrap pharmaceutical medicines.

• Suitable for products that require visual inspection of shrink process.

• Economical compared to conventional packing.

• Multiple packs can be shrunk simultaneously to save time and energy.

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SHRINK WRAPPING MACHINE

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LABELLING MACHINERY

• Labeling machines are machines that dispense and apply labels to various items like

products, containers, or packages.

• They are designed to apply labels to products and packages with variety of surfaces such

as fiber drums, aluminum, glass, steel and plastic.

• There is a wide range of labeling machines on the market, ranging from high production

units that allow for complete automation of the print and apply process to manual devices

that provide for simple label dispensing.

• Manufacturers make labels for numerous purposes, such as shipping addresses, product

information, bar codes and inventory control and pricing.

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TYPES OF LABELLING MACHINES

• There are two types of labelling machines.They are:

Semi automatic labelling machine

Fully automatic labelling machine

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SEMI AUTOMATIC LABELLING MACHINE

• Semi Automatic Labelling Machine are suitable for labelling on Round Vials,

Bottles.

• No change of parts is required for change in size of containers & labels suitable

for Glass, Plastic, Composite Containers can be prepared.

• Grooved and Brut Shaped Bottles can also be labeled.

• The Semi Automatic Labelling Machine incorporates latest sophisticated

Microprocessor Controlled Stepper Motor Drive, Fiber Optic Label and Container

sensing system.

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SEMI AUTOMATIC LABELLING MACHINE

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FULLY AUTOMATIC LABELLING MACHINE

• Fully Automatic Labelling machine is useful to place label accurately on round

shape of product.

• Full or partial wrap labeling can be possible.

• A unique feature of machine is if the body diameters changes, than also machine

operates without change in part.

• Products of different diameter like small size of vials and bottles upto containers

can be accommodated in the same machine & Speed is depend on the length of

label.

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• Different types such as Alluminium, Glass, Plastic products can be accommodated

on the machine.

• Labeling speed is automatically synchronized with conveyor speed to ensure

quality.

• Push and press optional attachment is used to ensure smooth labeling without

wrinkles or bubble.

• Adjustable angle of labelling heads is ideal for tapered products to conform

shapes.

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TYPES OF FULLY AUTOMATIC LABELLING MACHINE

• There are different types of Automatic labeling machines as follows:

Fully Automatic wrap around Labelling Machine

Fully Automatic double Side (top & bottom) Labelling Machines

Fully Automatic single side Labelling Machine

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FULLY AUTOMATIC WRAP AROUND LABELLING MACHINE

• Labelling around container.

• The label is wrapped around the container as the container is spun.

• This can be accomplished with a semi-automatic labeler or a fully automatic

labeling system.

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FULLY WRAP AROUND LABELLING MACHINE

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FULLY AUTOMATIC DOUBLE SIDED LABELLING MACHINE

• Labels are applied on a fully automatic labelling system.

• Products include any tray product, clam shell containers, boxes and cartons.

• Many times custom labelling systems are designed for top and bottom

labeling applications

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FULLY AUTOMATIC SINGLE SIDE LABELLING MACHINE

• Labelling a product from above.

• The label is placed on to product from above or one side of the container.

• Applications include clam shell containers, cartons, container caps or lids.

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FULLY AUTOMATIC SINGLE SIDE LABELLING

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ADVANTAGES OF LABELLING MACHINERY

• Quick change over design and virtually ‘tool less’ operation.

• Available with latest technology for precise accuracy and higher speed.

• Labels can be created in a multitude of designs and colors to ensure that there is a

proper label for every product need.

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PRINTING MACHINERY

• Printing machinery are used for printing tablets, soft gelatin capsules, hard

gel caps, freeze dried products (lab scale machine and other models for one-

side or double-sided printing).

• For the packaging (blister, foil)we can build a machine accordingly your

needs (a stand-alone type or a linear component) based on a combination of

various technologies.

• All the machines are built following the cGMP-5 rules.

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• The tablet printing machine is designed for one or double-sided printing in one or

several colours. 

• All forms of tablets, soft & hard gels, caplets can be printed. 

• In function of tablet size and shape, the printing capacity is 100 000 - 400 000

pieces/hr.

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BENFITS OF PRINTING:

• Protect your product from counterfeiting

• Reduce medical errors

• Print bar and data-matrix codes

• Differentiate your product

• Double sided and multi colour printing

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TYPES OF PRINTING MACHINERY

o Kyanite

o Platinium

o Saffir

o Quartz

o Modulo

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KYANITE• This machine is used for high production speeds and very accurate prints.

• The KYANITE can be used as stand-alone machine or integrated into a production

line.

• Options like automatic pad cleaning,rotary table, etc. are easily integrated.

• High speed printing machines with high accuracy up to +/- 0,05 mm

• Auto-blowing air ensures quick ink drying

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KYANITE

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ADVANTAGES:

• Closed ink cup

• No solvent evaporation or odour spread

• No ink waste, only printing consumes ink

• Ink cartridges are easily refillable

• Automatic pad cleaning

• Rotary table

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PLATINIUM• PLATINIUM pad printing belongs to the top of our standard printing machines.

• The simple and user friendly equipment allows individual adjustment of every

movement on the machine from the front LCD display including delay times

between movements to help with those difficult printable products.  

• Closed ink cup system allowing quick, easy change-over and reduction of odour

and solvent evaporation.

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• Independent actuation of every movement,

ink take-up, ink deposit, inking in steps,

continuous inking, performance of a

complete print cycle, continuous printing

with adjustable interval between successive

print cycles.

• Rotary table for multicolour printing

without loss of ink volume.

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SAFFIR• SAFFIR combines time-efficiency and ease of operation with consistent high-quality

end results.

• Every single step of the printing-cycle can be individually set, tested, and adjusted,

regardless of whether you want to run a single cycle or print continuously, it is

possible, at any point in time, to fine-tune the distance the pad travels to the product.

• The SAFFIR is available either as a table-top model, or fitted to a floor stand, in which

case it comes with a height-adjustable product table.

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SAFFIR

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QUARTZ

• It is a Electro-pneumatic pad printing machine .

• It is available with closed ink cup or with open ink tray.

• The QUARTZ-machine combines time-efficiency and ease of operation, every

single step of the printing-cycle can be individually adjusted.

• Ink cartridges and printing plate are quickly changeable

• The open ink tray has the same high performance as the closed ink cup systems.

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QUARTZ MACHINE

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MODULO• 2 - 4 closed ink cups (Ø 90, Ø 130 or Ø 160 or mixed)

• Automatic pad cleaning.

• Operated by touch screen panel.

• Executed with rotary table for two or four positions for automation with

pretreatment, end-drying or ejection of the objects.

• When the machine is restarted, the new additional features are automatically enabled

by the software.

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MODULO MACHINE

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CONCLUSION

• Machinery used for packing,printing and labelling should be less expensive

and most productive.

• They should be more reliable and rapid.

• They should be easy to clean and maintain.

• Automatic machines are mostly beneficial because it requires less labour.

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REFERENCES

•The Theory and Practice of Industripharmacy by

L.lachman,H.A.Liberman,JL.Kanig.

•Modern Pharmaceutics by Banker,Vol 72,Marcel

Dekker,NY.

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THANK YOU