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MACHINERY USED FOR PACKING,LABELLING AND PRINTING FOR DIFFERENT DOSAGE FORMS

MACHINERY USED FOR PACKING,LABELLING ANDPRINTING FOR DIFFERENT DOSAGE FORMSMENTOR:Prof. Dr. R. NAGARAJU M.Pharm.,Ph.DDept.Of PharmaceuticsPRESENTED BY:P. SRAVANI 2015MPH40017Dept.Of PharmaceuticsSPMVV - TIRUPATHI

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CONTENTS:Purpose of packing,Labelling and Printing.Packing MachineryLabelling MachineryPrinting MachineryConclusionReferences2

PURPOSE OF PACKING, LABELLING AND PRINTINGContainmentInformation transmissionPhysical and barrier protectionTransportDisplay3

PACKAGING MACHINERYPackaging machinery is used to package products or components. Packaging machinery includes related machinery for sorting, counting, and accumulating.There are many different types of packaging machinery. Common packaging machinery types include: accumulators, batching machinery, bagging machinery, sleever machinery, box making machinery, bundling machinery, capping machinery, Cartoning machinery, and closing machinery4

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PACKAGING MACHINERY Blister packing machine Capsule filling machine Ampoule and vial filling machine Tube filling machine Shrink wrapping machine5

BLISTER PACKAGING MACHINEIn pharmaceutical industry Blister Packaging Machines are used for the packing tablets, capsules, pills and other similarproducts packing.The packing process start with the capsules or tablets being loaded into a hopper and then into a feeder, which in turn can either be linear feeder or a brush box feeder depending on the shape of the product and also the material to be used.Heated rollers in the machine use different plastic films to form blisters that are subsequently filled with tablets.Some machines make use of alluminium foil to form blisters.6

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Machines are manufactured according to the size, depth and material used to form blisters.After tablets have been inserted in the formed blisters, cavities are heat sealed using foil.Blister Sealing Machines are used to seal filled plastic blister to a piece of coated carton board, by heat. The blister is kept in the sealing die which has the same shape as that of the cavity. The cavities are then filled and sealed by a foil using heat.Blister Trimming Machines are used for cutting, trimming the sealed blister or formed blister packs 7

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BLISTER PACKING MaCHINE9

CAPSULE FILLING MACHINEHigh Speed Automatic Capsule Filling machines are suitable for filling powders and pellets. These are versatile machineswith several outstanding features both functional and mechanical.The machines have capabilities to give an output of 40,000 capsules and 90,000 capsules per hour with high filling accuracy and can accommodate capsule sizes.Capsule fillers are used to fill hard gelatin and non gelatin capsules with pre determined quantity of liquids, powders, pellets, tablets.

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Capsules are normally fed into the machine, the filler then align, opens and accurately fills each capsule and recloses.Fillers generate minimum dust with lowest level of product loss. Non-separated, double loaded capsules and improperly inserted capsules are automatically rejected by machines to maintain the consistency in the quality of product.Most capsule fillers are characterized with fast changeover time to accommodate a variety of capsules in terms of shapes and size.

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TYPES OF CAPSULE FILLING MACHINEModel - A 4040,000 capsules per hour for powder 30,000 capsules per hour for pellets.Model - A 9090,000 capsules per hour for powder 70,000 capsules per hour for pellets.

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Semi automatic capsule filling machine

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AUTOMATIC CAPSULE FILLING MACHINE

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Advantages:

High Quality Capsule Filling Machine requires minimal maintenance and easy to clean.Another important feature is the installation of speed adjusting equipment and automatic counters ensuring the right quantity of capsules being filled and packed.

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AMPOULE FILLING MACHINEAmpoule filling machines are completely cover the product in the inert glass and do not have a rubber stopper or anyother material in direct contact with the drug.Ampoule filling machines can be used to fill ampoules as well as vials and the speed varies according to the technology.Certain ampoule coding machines apply ring banding to the completed ampoule tips for accurate identification.Filling range of these machines is normally between 1ml to 20 ml.Most ampoule fillers are characterized with fast changeover time to accommodate a variety of ampoules in terms of shapes and size.

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Advantages:High quality Ampoule filling machines require minimal maintenance and are very easy to clean.The installation of speed adjusting equipment and no ampoule no fill capability to ensure that unfilled ampoules are not packed.Check weight mechanism of the machine helps to maintain consistency in each batch.Sealing is done either by laser sealing system or conventional gas flame.

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AMPOULE FILLING MACHINE18

LIQUID FILLING MACHINELiquid Filling Machines are specialized machines used to fill bottles, vials, ampoules and other containers with predetermined quantity of liquids.These machines adopt a volumetric piston filling mechanism for smooth liquid filling.These machines are easy to operate and fill precise quantity of liquid into containers19

TYPES OF LIQUID FILLING MACHINEVaccum liquid filling machine: It is best suited for filling liquids that are foamy and caustic in nature.Automatic liquid filling machine: Automatic anti-pressure liquid filling machine adopting the ways of vacuum filling to fill all various of overflow products with high accuracy and versatility ensure filling without leakage, no foam and damaged bottle is not incorporated.

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Semi automatic liquid filling machine: volumetric liquid filling machine works on volumetric principle. The desired volume can be adjusted. Bottles are kept bellow the nozzles manually. 21

Advantages:Filling equipment allow adjustment of different sized bottles without changing parts and also have 'No Bottle-no fill' mechanism.Most machines meet the GMP norms and are easy to clean and maintain.The output of these machines depends whether they are semi or fully automatic.Liquid Filling machines are generally used in Pharmaceutical and chemical industries

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LIQUID FILLING MACHINE

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TUBE FILLING MACHINEAutomatic Tube Filling Machines fill ointment/cream in cylindrical alluminium collapsible/coextruded plastic tubes and close it absolutely safely and symmetrically.The empty tubes are first loaded in the cassette, which then travels through the guides to be held in the feeder by vacuum.The tube is then fed into the tube holder by the feederwhen the tube is lifted, its presence is checked by a sensor and this signal is relayed to the filling station. Hence if a tube is not there, the dosing action does not take place and hence there is no fill.

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If the tube is not ejected out by the ejector, the machine stops in order to avoid damages.In case of any jamming on the indexing system, to avoid breakages, the load is sensed & the machine stops automatically.Blow off device and tail cutting arrangements to avoid the paste / cream touching the sealing portion of the tube.

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TUBE FILLING MACHINE

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Advantages:Audio visual Alarm Annunciation System for any abnormal conditions of the machine.Comprehensive control panel with all protection features.

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SHRINK WRAPPING MACHINEShrink wrap machines make use of plastic to effectively seal a container or product by tightly surrounding it.Vacuum shrink wrapping can prevent bacteria form entering the product and also protect them form wear and tear during transportation.The process involves tightening a thermoplastic film around the product and shrinking it by heat.It also helps to add strength to the stack, making it dust, water and tamper proof.

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Advantages:

L-Bar sealers are used to pack products with the help of electricity rather than heat. Heat guns are used to wrap blister packs.Vacuum sealers are used to shrink wrap pharmaceutical medicines.Suitable for products that require visual inspection of shrink process.Economical compared to conventional packing.Multiple packs can be shrunk simultaneously to save time and energy.29

SHRINK WRAPPING MACHINE30

LABELLING MACHINERYLabeling machines are machines that dispense and apply labels to various items like products, containers, or packages.They are designed to apply labels to products and packages with variety of surfaces such as fiber drums, aluminum, glass, steel and plastic.There is a wide range of labeling machines on the market, ranging from high production units that allow for complete automation of the print and apply process to manual devices that provide for simple label dispensing.Manufacturers make labels for numerous purposes, such as shipping addresses, product information, bar codes and inventory control and pricing.

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TYPES OF LABELLING MACHINESThere are two types of labelling machines.They are: Semi automatic labelling machine Fully automatic labelling machine32

SEMI AUTOMATIC LABELLING MACHINESemi Automatic Labelling Machine are suitable for labelling on Round Vials, Bottles.No change of parts is required for change in size of containers & labels suitable for Glass, Plastic, Composite Containers can be prepared.Grooved and Brut Shaped Bottles can also be labeled.The Semi Automatic Labelling Machine incorporates latest sophisticated Microprocessor Controlled Stepper Motor Drive, Fiber Optic Label and Co