Reactions 1196 - 5 Apr 2008

Imipramine

Hyperpigmentation: case reportA 63-year-old woman, who had been receiving imipramine

200 mg/day for 30 years for depression, presented with slate-grey pigmentation of her face and the dorsal areas of herhands. The hyperpigmentation had progressively worsenedover the previous 3 years. An examination revealed bluish-greyperiorbital pigmentation with general blue-greyhyperpigmentation in a photodistribution on her face and thedorsal aspects of her hands. A punch biopsy taken from hercheek showed golden-brown granules in the upper and middermis. A Fontana-Masson stain for melanin was positive.[Patient outcome not stated.]Mehr N, et al. Imipramine-induced hyperpigmentation of the skin. DermatologyOnline Journal 13: 8, No. 4, 13 Oct 2007 - USA 801104274

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Reactions 5 Apr 2008 No. 11960114-9954/10/1196-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved