Reactions 1365 - 20 Aug 2011

SRopivacaine

CNS toxicity treated with soya oil emulsion: casereport

A 24-year-old man, who was undergoing elective openreduction and internal fixation of a fractured left clavicle,received 40mL of 0.5% ropivacaine, injected in 5mLincrements, as a brachial plexus block. About 1.5 hourslater, following his operation, he was restless, incoherent,talkative, inarticulate, and his speech was slurred andirrational. He was diagnosed with ropivacaine-inducedcentral nervous system (CNS) toxicity, and received lipidemulsion therapy. All neurological derangementsdisappeared and he recovered consciousness. He had nofurther symptoms and was discharged without sequelae.

Author comment: "[W]e report a case of ropivacaine-induced CNS toxicity treated successfully by lipid emulsion."Mizutani K, et al. Successful treatment of ropivacaine-induced central nervoussystem toxicity by use of lipid emulsion: Effect on total and unbound plasmafractions. Journal of Anesthesia 25: 442-445, No. 3, Jun 2011. Available from:URL: http://dx.doi.org/10.1007/s00540-011-1125-4 - Japan 803059154

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Reactions 20 Aug 2011 No. 13650114-9954/10/1365-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved