8/9/2019 DR SARMA'S DERMPATH: Acantholytic Acanthoma ( Epidermolytic Acanthoma), M 65, neck,

1/5

Acantholytic acanthomaAcantholytic acanthoma

(Epidermolytic acanthoma)(Epidermolytic acanthoma)

Deba P Sarma, MDDeba P Sarma, MD

OmahaOmaha

8/9/2019 DR SARMA'S DERMPATH: Acantholytic Acanthoma ( Epidermolytic Acanthoma), M 65, neck,

2/5

Compact hyperkeratosis, acanthosis, papillomatosis

M 65, neck

8/9/2019 DR SARMA'S DERMPATH: Acantholytic Acanthoma ( Epidermolytic Acanthoma), M 65, neck,

3/5

Acantholysis with periperinuclear vacuolization

involving all layers of the epidermis except the basal

layer

8/9/2019 DR SARMA'S DERMPATH: Acantholytic Acanthoma ( Epidermolytic Acanthoma), M 65, neck,

4/5

Hypergranulosis with large basophilic keratohyanine

granules and intracytoplasmic amorphous

eosinophilic bodies

8/9/2019 DR SARMA'S DERMPATH: Acantholytic Acanthoma ( Epidermolytic Acanthoma), M 65, neck,

5/5

Acantholytic acanthomaAcantholytic acanthoma(Epidermolytic acanthoma)(Epidermolytic acanthoma)

Single asymptomatic papule or nodule in trunk, arms,Single asymptomatic papule or nodule in trunk, arms,neck; genital lesions may be multiple.neck; genital lesions may be multiple.Age: Elderly (median age 60), M>FAge: Elderly (median age 60), M>F

Benign epidermal tumor with a characteristic histologicBenign epidermal tumor with a characteristic histologicpicture of acantholytic hyperkeratosis.picture of acantholytic hyperkeratosis.

Compact hyperkeratosis, acanthosis, papillomatosis.Compact hyperkeratosis, acanthosis, papillomatosis.

Acantholysis with periperinuclear vacuolization involvingAcantholysis with periperinuclear vacuolization involvingall layers of the epidermis except the basal layer.all layers of the epidermis except the basal layer.

Hypergranulosis with large basophilic keratohyanineHypergranulosis with large basophilic keratohyaninegranules and intracytoplasmic amorphous eosinophilicgranules and intracytoplasmic amorphous eosinophilicbodies.bodies.