Reactions 1348 - 23 Apr 2011

Imipramine

Tachycardia and hypertension: case reportA 35-year-old man developed sinus tachycardia and

hypertension during treatment with imipramine.The man was diagnosed with major depression and

started receiving imipramine which was titrated to 50mgdaily in 2001 [initial dosage and route not stated]. In January2009, his imipramine dosage was increased to 100mg dailydue to exacerbated depression. In early April, he found tohave tachycardia (140 beats/min) during a check-up.Additionally, he had a BP of 145-156/80-85mm Hg. Noepisodes of palpitations, dyspnoea, chest pain, facialflushing, headache or dizziness were noted. An ECGshowed sinus tachycardia. Drug-induced sinus tachycardiaand hypertension were suspected.

Imipramine was gradually tapered and he startedreceiving fluoxetine. In July, his BP was 116/72mm Hg andhe had a hear rate of 75 beats/min.Tarn TKW, et al. A young man with asymptomatic sinus tachycardia. Hong KongPractitioner 32: 179-182, No. 4, Dec 2010 - Hong Kong 803053320

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Reactions 23 Apr 2011 No. 13480114-9954/10/1348-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved