Reactions 1500, p29 - 10 May 2014

SOcriplasmin

Panretinal dysfunction: case reportA 63-year-old woman developed panretinal dysfunction

following intravitreous injection of ocriplasmin [outcome notstated].

The woman developed brilliant white photopsias severalhours after intravitreous injection of ocriplasmin0.125mg/0.1mL in the right eye for a small macular hole withvitreomacular adhesion. These photopsias progressed intomultiple white floaters on a black background, with noperceptible vision in the injected eye. Although her visionimproved over the next 4 days, she experienced nyctalopia andher vision developed a yellow tint. Nine days after injection,her corrected visual acuity was 20/125 in the right eye and20/25 in the left eye. Fundus biomicroscopy showed aprepapillary vitreous ring in the right eye, with a full-thicknesshole in the macula and diffuse attenuation of the retinalarterioles. Spectral-domain optical coherence tomography ofthe right eye demonstrated an enlarged full-thickness macularhole, with attenuation or loss of the external limitingmembrane, photoreceptor ellipsoid layer and cone outersegment lips line. All isopters in the right eye were constricted.Electroretinography in the right eye showed that the rod B-wave was reduced to <10% of normal, the combined rod-coneresponse was reduced to ~50% of normal, and the 32-Hzflicker was reduced to ~40–50% of normal. Oscillatorypotential amplitudes were severely reduced in the right eye.

Author comment: The patient developed "acute severepanretinal dysfunction after ocriplasmin injectiondocumented and quantified by fundus photography,Goldmann visual field testing, spectral-domain opticalcoherence tomography, and electrophysiological responses."Fahim AT, et al. Acute panretinal structural and functional abnormalities afterintravitreous ocriplasmin injection. JAMA Ophthalmology 132: 484-486, No. 4,Apr 2014 - USA 803103064

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Reactions 10 May 2014 No. 15000114-9954/14/1500-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved