Reactions 417 - 5 Sep 1992

Bupivacaine

Seizures in children: 2 case reportsTonic clonic seizures developed in 2 girls following

extended continuous infusions of bupivacaine forpostoperative pain relief.

Patient 1, a 3-year-old girl, experienced 2 seizures 21 hoursafter the initiation of an intrapleural bupivacaine infusion0.25-0.5 mg/kg/h. The second patient, a 9-year-old girl,experienced 3 seizures beginning 56h after the initiation of anepidural bupivacaine infusion 1.25 mg/kg/h with epinephrine.The blood levels of bupivacaine were 5.6 and 5.4 µg/ml inpatient 1 and 2, respectively.

Bupivacaine was promptly discontinued in both patients andIV phenobarbital given to control seizures. The remainder ofthe hospital stay was uneventful in both patients. [See alsoViews and Reviews, p4].Agarwal R, et al. Seizures occurring in pediatric patients receiving continuousinfusion of bupivacaine. Anesthesia and Analgesia 75: 284-286, Aug 1992 -USA 800152168

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Reactions 5 Sep 1992 No. 4170114-9954/10/0417-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved