Reactions 1264 - 8 Aug 2009

Clomipramine

Pisa syndrome: case reportA 56-year-old woman, who was prescribed

clomipramine 9 x 25mg tablets daily for depression inSeptember 2003, developed left trunk flexionapproximately 2 months after starting the medication.Examination revealed left trunk flexion, shift of her centre ofgravity to the left, and mildly unstable gait. Horizontal x-rays showed a lateral long C curve and Cobb angle of 30°.Pisa syndrome was suspected and her clomipraminedosage was reduced to 3 x 25mg tablets daily. About2 weeks after the dosage reduction, her abnormal posturesgradually improved and, after 1 month, her trunk flexionresolved. As of March 2007, she had normal gait.

Author comment: "Pisa syndrome occurs rather rarely asan adverse effect related to antidepressant medications."Uemura T, et al. Pisa syndrome. Journal of Spinal Disorders and Techniques 21:455-457, No. 6, Aug 2009 - Japan 801146937

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Reactions 8 Aug 2009 No. 12640114-9954/10/1264-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved