Reactions 520 - 24 Sep 1994

Imipramine

Sexual function disorders: incidence studyImipramine maintenance therapy does not appear to

adversely influence the level of sexual interest or pleasure inpatients with recurrent major depression, according to theresults of a US study.

A group of 71 women and 19 men, of mean age 40 years,completed at least 6 months of maintenance therapy witheither imipramine [dosage not stated; n = 45] or placebo (46).All patients had a baseline Hamilton Rating Scale forDepression of > 15. In contrast to previous findings with acuteimipramine therapy, there was no association betweenmaintenance imipramine treatment and the level of sexualfunctioning of both the men and women.Karp JF, et al. Imipramine and sexual dysfunction during the long-term treatmentof recurrent depression. Neuropsychopharmacology 11: 21-27, Aug 1994 -USA 800302025

1

Reactions 24 Sep 1994 No. 5200114-9954/10/0520-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved