Reactions 1046 - 9 Apr 2005

★Mepivacaine

First report of urticaria: case reportA 35-year-old woman developed urticaria and pruritus on

her face, neck and legs 15 minutes after receiving mepivacaine[dosage not stated] during removal of a naevus. Urticariaresolved within 1 hour after treatment with an oralantihistamine. One year later, prick and intradermal tests werenegative to 1% mepivacaine, but a subcutaneous challengewith mepivacaine 0.3mL resulted in a 23 × 10mm wheal after15 minutes. Subsequent intradermal tests were positive tomepivacaine and ropivacaine, but subcutaneous challengeswith lidocaine and bupivacaine were negative.Prieto A, et al. Urticaria due to mepivacaine with tolerance to lidocaine andbupivacaine. Allergy 60: 261-262, No. 2, Feb 2005 - Spain 800979969

» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of urticaria associated withmepivacaine. The WHO Adverse Drug Reactions databasecontained 61 reports of urticaria associated with mepivacaine.

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Reactions 9 Apr 2005 No. 10460114-9954/10/1046-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved