Reactions 1223 - 11 Oct 2008

Ropinirole

Diaphoresis and sleep disorders during smokingcessation: case report

During smoking cessation, a 54-year-old woman developeddiaphoresis and sleep disorders while receiving ropinirole forrestless legs syndrome.

The woman, who was stable during treatment withropinirole 1 mg/day for 2 years [duration of treatment notclearly stated], quit smoking and, about 4 days later, shedeveloped profuse diaphoresis at night, which required her tochange her shirt most nights because it was wet. She also hadmore disturbed sleep with increased awakenings for severalnights consecutively.

The woman decreased her ropinirole dosage by half; shetook 0.5mg at night instead of 1.0mg. By the second night atthe reduced dose, she had no diaphoresis at night and noincreased awakenings; of note, she had full relief of herrestless legs syndrome.

The woman increased her ropinirole dose back to 1mg for2 nights, but the diaphoresis and awakenings recurred. Hersymptoms resolved when she returned to the half dose of0.5mg. She also had good control of restless legs syndrome.Juergens TM. Adverse effects of ropinirole-treated restless leg syndrome (RLS)during smoking cessation. Journal of Clinical Sleep Medicine 4: 371-372, No. 4,2008 - USA 801126001

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Reactions 11 Oct 2008 No. 12230114-9954/10/1223-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved