1 protein crystallography. 2 ban, n., nissen, p., hansen, j., moore, p. b., steitz, t. a. science...

1

Protein CrystallographyProtein Crystallography

2

Protein CrystallographyProtein Crystallography

Ban, N., Ban, N., Nissen, P., Nissen, P., Hansen, J., Hansen, J., Moore, P. B., Moore, P. B., Steitz, T. A.Steitz, T. A.ScienceScience 289 289 pp.pp. 905 (2000) 905 (2000)

3

Protein CrystallographyProtein Crystallography

Aspecific acid phosphatase from E. coli

4

DNA PolymeraseDNA Polymerase

5

ATP synthesisATP synthesisATP synthesisATP synthesis

Cell (plant)Cell (plant)

mitochondriamitochondria

6

ATP synthesisATP synthesisATP synthesisATP synthesis

CellCell

Innermitochondrialmembrane

Innermitochondrialmembrane

7

ATP synthesisATP synthesisATP synthesisATP synthesis

Surface of theinner mitochondrialmembrane

Surface of theinner mitochondrialmembrane

8

ATP synthesisATP synthesisATP synthesisATP synthesis

Section of theinner mitochondrialmembrane

Section of theinner mitochondrialmembrane

NADH oxidaseNADH oxidaseCytochromeCytochromeCitochromeCitochromeC oxidaseC oxidase

ATP synthase

9

ATP synthaseATP synthaseATP synthaseATP synthase

ATP synthase fragment F1

Abrahams, J. P.,Abrahams, J. P.,Leslie, A. G., Leslie, A. G., Lutter, R., Lutter, R., Walker, J. E.Walker, J. E.NatureNature 370 370 pp.pp. 621 (1994) 621 (1994)

10

ATP synthaseATP synthaseATP synthaseATP synthase

The ADP binding site in ATP synthase

11

ATP synthaseATP synthaseATP synthaseATP synthase

ATP ATP synthase synthase mechanismechanismm