Reactions 1381 - 10 Dec 2011

SCitalopram

Hepatotoxicity in an elderly patient: case reportAn 83-year-old man was admitted 4 days after beginning

treatment with citalopram 20 mg/day [route not stated] forsuspected depression. Investigations revealed an AST of1 516 U/L, ALT of 1 155 U/L, GGT of 111 U/L, alkalinephosphatase of 222 U/L, and LDH of 2 324 U/L. Citalopramwas withdrawn and his aminotransferase levels normalisedin 5 days.

Author comment: The assessment of causality was carriedout by the application of . . . the Naranjo scale (probable: 6points), the CIOMS/RUCAM scale (probable: 6 points) andMaria and Victorino’s CDS scale (probable: 14 points).Rubio Merino MI, et al. Hepatotoxicidad por citalopram [Citalopramhepatotoxicity]. Medicina Clinica 136: 270-271, No. 6, Mar 2011 [Spanish;summarised from a translation] - Spain 803063544

1

Reactions 10 Dec 2011 No. 13810114-9954/10/1381-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved