Reactions 1371 - 1 Oct 2011

SClomipramine

Acute hepatotoxicity: case reportA 18-year-old girl presented with a major depressive

episode, according to DSM IV criteria. She started onclomipramine initially at 25 mg/day; by day 4, her dosagehad increased to 75 mg/day [route not stated]. However,she developed a marked weakness by day 7; herbiochemical tests revealed increased AST and ALT levels of212 IU/L and 474 IU/L, respectively. Clomipramine wasdiscontinued. Her AST and ALT levels gradually decreasedand normalised after one month.

Author comment: "In the present case, a causalassociation between clomipramine and hepatotoxicity can beproposed."Atmaca M. Acute severe hepatotoxicity associated with clomipramine. KlinikPsikofarmakoloji Bulteni 21: 154-155, No. 2, Jun 2011. Available from: URL:http://dx.doi.org/10.5455/bcp.20110706030609 - Turkey 803060793

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Reactions 1 Oct 2011 No. 13710114-9954/10/1371-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved