Reactions 1181 - 8 Dec 2007

Imipramine

Extrapyramidal symptoms in a child: case reportA 10-year-old girl had been receiving methylphenidate and

valproic acid for 1 year for the treatment of attention-deficithyperactivity disorder and childhood bipolar disorder. Shestarted receiving imipramine 25 mg/day for depressive moodand aggression. On day 3 of the treatment, she developedoculogyric crisis symptoms. The symptoms included ocularpain and a sustained upward gaze. She received an IM dose ofbenzatropine. Within a few hours, her oculogyric crisissymptoms improved completely. Her blood valproic acidconcentration was normal. Imipramine was discontinued. Shecontinued to receive methylphenidate and valproic acid for1 year. She did not experience any recurrence ofextrapyramidal symptoms.

Author comment: "It seems that the [extrapyramidalsymptoms] were related to imipramine."Tahiroglu AY, et al. Imipramine, methylphenidate and valproic acid-related EPS ina child: a case report. International Journal of Neuropsychopharmacology 10:705-707, No. 5, Oct 2007 - Turkey 801088531

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Reactions 8 Dec 2007 No. 11810114-9954/10/1181-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved