Reactions 441 - 6 Mar 1993

Imipramine

Hypertension in adolescents: incidence studyA retrospective Texan study showed that 9/15 adolescent

psychiatric inpatients receiving imipramine 75-250 mg/dayhad developed hypertension during treatment. Patients aged13-15 years had a significantly higher incidence ofhypertension than those aged 16-17 years and 4 adolescentswere hypertensive despite subtherapeutic imipramineconcentrations Hypertension developed within the first 7weeks of imipramine therapy With continued treatment, 5patients remained hypertensive without subjective sequelae,and hypertension in the remaining patients resolved Authorcomment: ‘Although other studies have noted the increase inBP associated with imipramine, this is the first study todocument a high incidence of imipramine-inducedhypertension in adolescent psychiatric inpatients.’Kuekes ED, et al. Hypertension is a risk in adolescents treated with imipramine.Journal of Child and Adolescent Psychopharmacology 2: 241-248, No. 4, 1992 -USA 800181718

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Reactions 6 Mar 1993 No. 4410114-9954/10/0441-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved