ksr rs bzap2

1Dr. K. Shiva Rama Prasad, at http://technoayurveda.wordpress.com/

Excellence of Rasaaushadhi In Ayurveda Practice – Part 2

Our Role in Establishment of

Rasa-Aushadhi Glory in

General Ayurveda Practice Instead of cursing the darknessTry to lit a small LIGHT –It becomes FLAMEone day to cook your food

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ATechnoayurveda International

Presentation In

Association withAyurmitra

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స

“రస” దుయలకు అ నందనల

Rasashastra Re-Orientation Program at NRS Govt. Ayurveda College, Vijayawada

on 15-12-2009

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न

च

रसशासतर

धातवादाथरमवित

मनतवयद

हवधदवार

मकत

र

व परम योजनतवात

रसशवर

दशरन

Dhatuvada - Dehavedha

Excellence of Rasaaushadhi In Ayurveda PracticeRasa Aushadhi Common Diseases in GAP Research in RT

Dr. K. Shiva Rama Prasad, at http://technoayurveda.wordpress.com/

Conversion of the lower metals to higher is the job of “Chemistry”.

What is expected from “Rasashastra” is to

make is the “Dehavedha” for the body to attain the “Mukti” from “Disease”

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Introduction



• Rasashastra a Scientific Chemotherapy of Ayurveda is at Cross-Roads

• The influences and advancements of -– “Pharmacy standards”– “Evidence Based Medicine protocols”– A major Global “Toxic concept campaign” and – “Ayurveda Fraternity Deception”

• - are making panic to the Ayurveda community in general and Rasashastra (Pharmacy) division in specific.

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• The Excellency to bring back – Research in the any branch especially in Rasashastra is essential.

• Ayurveda has many units of Research like – CCRAS, ICMR and many NGOs for making Research and informing the Research fruits to the user.– Whether the Researches in Ayurveda are

User demand fulfillments?– Are the Researches followed are up to

the International standard to accept Globally our Medicine?

– Are we make user to satisfy by the –• “Standard”• “Effect” or • “Free of Toxicity”• By any other way . . . At least . . .

Ayurveda in Research



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• To be frank the researches in Ayurveda are not user friendly and could not reach the ultimate user – General Ayurveda Practitioner

• As we are at the Rasashastra researches in concern at present – it is necessary to know how the researches are made in this branch.

Need of the Hour



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• Researches are of many folds to obtain the “True Knowledge” – A search again and again to get the perfect knowledge.

• Commonly followed are –– 1. Explorative Research

• Literary • Experience survey

– 2. Conclusive • Descriptive• Experimental

Research in General



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• Problem definition• Objectives set: purpose – place – status - means

– Research questions – Hypothesis– Boundary of the study

• Research design– Sampling – experiment – questioners

• Data collection• Data analysis• Interpretation of results – should be with real world

problem and conclusion • Validation of results

Research Process



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Is Rasa-Medicine is Target oriented?


Rasa Parpati

Parada Gandhaka

Samanya Shodhana

Lashuna + Saindhava

with Lime Powder

Samanya Shodhana Godugdha

Bhringaraja

Ghrita Bharjita Shodhita Gandhaka

Hingulottha Parada

Shodhita ParadaParpati 2 of 4

Parpati 1 of 2

What Target differences are brought in usage of these combinations and permutations with set of combinations

and permutations of Anupana, Sahapana in General Ayurveda Practice

Excellence of Rasaaushadhi In Ayurveda Practiceushadhi Common Diseases in GAP Research in RT Activity in Research

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A cutting edge technology is the need of hour in Ayurveda. The road beyond Production & Practice should be visualized.

Is Rasa-Medicine is Target oriented?



Dravya Shodhana Probable?Parada Hingulotha (Alimentary) Pittahara?

Lime powder (Ca+)(neural) Vatahara?

Lasuna + Saindhava

(Tissue invader) Kaphahara?

Gandhaka Godugdha Agni?Bhringaraj Panchabhutagni?

Whether the “Shodhana” makes the Dravya to reorganize the Chemical bonding?

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Parpati in Practice


Parpati Additives Target Rasa Rasa + Gandhaka

(Base combination)Annavaha, Udakavaha

Rasavaha, Lasika (Twak)Panchamruta + Loha, Abhraka

TamraAnnavaha, Pranavaha

SukravahaBola + Bola Rakta vaha, Artavavaha

Loha + Loha Annavaha, Lasika (Twak)

Swarna + Swarna Annavaha, PranavahaSukravaha

Tamra + Tamra, Vatsanabha

Annavaha, MootravahaLasika (Twak)

Sweta Soraka, Sphatika, Navasara

Annavaha, Mootravaha


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Who Answers ?


Ingredient

Shodhana

Multi combinations

Multiple Bhavana

Multiple Preparation methods

Marana

AnupanaSahapana

Aushadha Kaala

Phar

mac

eutic

al

Multiple Pharmacokinetics

Multiple Pharmaco- dynamics

Clinical attitudes

Single / Multiple Shodhita Ingredients

Raw drug collection - Identification

Drug Target Action?

Drug concentrations to maintain half life?

Drug Excretion ?


Is there any Genotoxicity ?

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Another Example of Kupipakwa Rasayana


• In Kupi pakwa Rasayana procedures – the medicine collection is from the “Talastha” or “Kantastha” and “Ubhayastha”.

• Taking the example of “Somanatha tamra Bhasma and Malla Sindhura (Tamra sindhura) are from one preparation.– The “Kantastha” – called as Tamra Sidhura acts on STI, Tamaka

Swasa– Where as – the “Talastha” collection called as Tamra Bhasma

acts on – many diseases, especially on Annvaha, Pranavaha, Twak vikara, etc.

• What makes the difference of collection in a process?• Whether the target is to prepare one medicine in a

pharmaceutical procedure or two Birds in one shot? • Does such short cut methods are encouraged by the Learned

community?


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• Literary research in Rasashastra has a wide scope and is the need of the hour.

• The print available Rasashastra books are few and the abundance of Manuscripts makes – a chance to explore Rasashastra.

• For Eg. – a preparation have many dialects of preparation methods – scrutinizing them makes us to have a target oriented potent Medicine to reach.

What Literary Research?

Excellence of Rasaaushadhi In Ayurveda Practice


ommon Diseases in GAP Research in RT Activity in Research Research Methods to Adopt

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• Survey and education of Rasa medicine usage in the practice is recorded –– What is the need for Practitioner?

• Symptom target • Disease target • Organ target • System target • Health target

– What medicines are causing the adverse effects? – Classified Recordings of -

• Hypersensitivity • Hepato toxicity • Nephro toxicity • Neuro toxicity

How to survey in RT



ommon Diseases in GAP Research in RT Activity in Research Research Methods to Adopt

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• Much of the present day Researches are following the Descriptive Method researches – which are with limited scope - as –

• Prospective study – common – Physico / Pharmaco -chemical studies – Drug effect in clinical study

• Retrospective study – Reverse pharmacology study - uncommon in Ayurveda

Do we do Descriptive Research in RT



mmon Diseases in GAP Research in RT Activity in Research Research Methods to Adopt

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Experimental studies have no pickup in Ayurveda because of non-efficiencies /exposure in maintenance of – Animal Houses and Analytical lab.

The limping or dependent studies are successful some times but not yielding the full-fledged fruits and results to the Ayurveda community.

More systematic animal experiments and lab studies are required as the AYUSH is funding and encouraging for the “Expressive Projects”

Experimental Research in RT



Research in RT Activity in Research Research Methods to Adopt Research Models

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• Best Research model for successful Penetration Rating in to market is through fulfilling the peoples needs –

• Mathematical –– Inventory – Parametric– Replacement

• Algorithmic – is a well-defined sequence steps to solve a problem – Combinational – Polynomial

Research Models in RT


Activity in Research Research Methods to Adopt Research Models


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• Present day researches seems to validate ancient formulations rather than productivity

• No contribution of the “Neo-Rasashastra” is brought forward

• An inventory model is –– Classify and visualize the old formula as TLC, HPTC,

Finger print technology, etc – Chemical structure is identified – Reconstruct the chains for validation and comparison – Restructure the combination to the needs of user– Rejuvenation of Vedic Chemistry – There by combating the present day dreadful diseases

Inventory Research




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• A classical design of Research (validation)– mere Chemical constituents – studied with -– Pre-fixed Parameters – Chemical structure evaluated – Limited framework to study

• A locality • One medicine • Small duration

– Mono-directional – Target based – Result oriented

Parametric Research




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• In Ayurveda – we are commonly using the substitutes –– Whether the replacements are equivalent?– Does they give exactly results as their substitutes?

– we don’t know!• Instead – using Replacement Research is

better – here we replace with –– Standard replacement – Equivalent replacement (based on Rasa, Guna, etc) – Omitting replacement – Complete replacement

Replacement Research




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• The medicines commonly used are of Herbo- mineral combinations

• The combinational research in Rasashastra is defined as –– A team of Rasashastra - Chemistry –

Botany – Pharmacy – Ayurveda Specialized Branch - are together to work on a compound – unbiased

– Various methods of said preparations are compared for the – structure – safety (Toxicity) – economy - efficacy –

Combinational Research


Excellence of Rasaaushadhi In Ayurveda PracticeResearch Methods to Adopt Research Models GAP in Research Conclusion

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• It is defined as - A mathematical function that is the sum of a number of terms –– As the standards of the Ayurveda are unique and not

fit to the “Rest of the World” –• A multi center – large sample – uni-directional studies are

invited – This is possible by the universities or CCRAS or ICMR –

creating a Nodal officer to control the studies all over – even the PG Centers

• A common minimum policy is created to ensure the

– Drug Safety– Half life – Target area and – Excretion

Polynomial Research



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• Reverse pathology in Ayurveda is said as – Samprapti Vighatana

• Planning of the Vighatana with the combination is the most important task in Ayurveda Practice. It is possible with the understanding of Ayurveda principles and application of –– Rasa– Guna– Veerya– Vipaka– Prabhava

• Reverse Pharmacology is understood under the present day technology about –– Drug Excretion– Drug target – Half life, etc

Reverse Pathology – Reverse Pharmacology



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• Bahumootrantaka Ras used in Madhumeha has –

• Ahiphena• Dadima• Kadali• Parad• Loha• Mouktika• Praval• Shalmali• Udumbara• Vanga

• Madhumeha patho-physiology is –– Tissues of body are liquidated -– The sugar reserves undertakes neo-

glucogenesis– Non utilization of CHO by muscles or

even for transformation in to deposits – Free CHO (Shareera Kleda) mix with

fluids (Ap Dhatu) of the body especially Rakta

– Expresses as “Bahudrava shleshma yukta – Madhurakta”

– The liquids mixed with CHO of the body are transported to the KUB – termed as - Madhumeha

– i.e. Elimination of excess fluids along with Shareera Kleda (Glucose)

– The reverse pathology planned on these grounds are – in RED – &

– Fluid Regulation – CHO Regulation

Example



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Ahiphena paralyzes sigmoid smooth mussels & Dadima prevents the fluid re absorption from colon by reverse peristalsis, Loha require maximum fluid for synthesis and absorbs the water once again – so, the fluid re- entry in to system is regulated at the same time Shalmali absorbs the fluid in the colon

Repatriation Hypothesis i.e. Reverse Pathology



Fluid Regulation

1

Same time the Urine re- absorption from Henley's loop is retarded by Vanga, and Kadali- Udumbara makes the integumentary system (Lasika) to constrain and fluid retained is drained back to system

2

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Repatriation Hypothesis i.e. Reverse Pathology



CHO Regulation

Formation of shareera kleda – CHO is through Liver (Mamsa Khanda) and Pancreas – there by the Parada acts as agent to and prevents the neo-glycolysis

CHO combustion is done through rapid muscle movements by initiating Acetylcholine at motor endplates in muscle fiber through - Mouktika – PravalaHeat generated with muscle movement makes the bahudrava shleshma to evaporate

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3

Shalmali, Parada initiates the

pancreas to regulate the CHO

5

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• General Ayurveda Practitioners Research models are with –– Involved Data base recording and – submission to the nearest center for analysis –

as a part of big survey • Suggesting the center for –

– epidemic and endemic events and – actively participating in Health campaigns with– Evidence based Research drugs provided by

the center in time

GAP Research Models


Excellence of Rasaaushadhi In Ayurveda PracticeActivity in Research Research Methods to Adopt Research Models GAP in Research

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• Area specific diseases are submitted and a common drug therapy modules are adopted as per the centers advise

• Center responsibilities -– Periodical CME for the practitioners with in 50 -100 KM

diameter – Door to door survey of health / disease conditions – Providing Easy access to the people about pro and

cant's of drug – Life line access through telephone / Internet in

Institutional / Hospital centers – Radio talks / TV shows / FM Radio services organized

to create Awareness to the Local people

GAP Research Models


Excellence of Rasaaushadhi In Ayurveda PracticeActivity in Research Research Methods to Adopt Research Models GAP in Research

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Responsibilities of Practitioner



• Reclassify the usage of Rasaaushadhi in – Infectious – Metabolic – Emergencies, etc

• Diseases of attention – AIDS – Cancer – ED – Paralysis

• Developing the databank for EB Ay Medicine • Defining the Rasaushadhi in Departmental use –

Shalya, Prasuthi, etc.• Suggestion of Contribution required in practice • Ethical practices in Rasa practice

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Conclusion



Research Methods to Adopt Research Models GAP in Research Conclusion

• The Interference of too many or • No involvement

– is the problem in Ayurveda Research• Developing Teamwork instead & Working

Unbiased in the Research and incorporating Rasaaushadhi vividly in General Ayurveda Practice are the solutions for development - because ….

–आरोगयम

(रस)

भाःकरािदचछ

त

32Dr. K. Shiva Rama Prasad, Professor & Head, Kayachikitsa, Amrita School of Ayurveda, Kerala

THANK YOUDr. K. Shiva Rama Prasad

Of . . . technoayurveda.wordpress.comon


Excellence of Rasaaushadhi In Ayurveda Practice – Part 2

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