Reactions 1274 - 17 Oct 2009

OMepivacaine overdose

Dysarthria, myoclonus and confusion followingmedication error, treated with soya oil emulsion:case report

A 19-year-old woman received local anaesthesia withmepivacaine for the repair of a wrist injury. Due to amedication error, she received a 50mL injection of 2%mepivacaine (1000mg) instead of 50mL of 1% mepivacaine(500mg). A few minutes later, she reported dysarthria; shesubsequently developed myoclonia of her arms whichprogressively worsened, and she became confused.Oxygen, clonazepam and midazolam were administeredwith no improvement. She received 100mL of 20% IV soyaoil emulsion [Medialipide] and her symptoms resolvedimmediately. Her surgery proceeded, which wasuneventful.Charbonneau H, et al. Early use of lipid emulsion to treat incipient mepivacaineintoxication. Regional Anesthesia and Pain Medicine 34: 277-278, No. 3, May-Jun2009 - France 801154053

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Reactions 17 Oct 2009 No. 12740114-9954/10/1274-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved