Antacid

Magnesium containing antacid causes hypermagnesaemla in infant Toiazoiine may be used in infanL~ with f\\.I\monary impairment. An\acids are often given in conjunction to prevent the risk of gastrointestinal haemorrhage. one of (he toxic effects of loialoiine. A 32·week-old infant with respiratory distress from streptococcal sepsis and pneumonia. was treated with ampicillin. gentamicin. pancuronium and hyperventilation, but with a low pulmonary artery oxygen tension. lolazoline was given. plus a magnesium­containing antacid. 4mllcontaining 56mg MG .. ) 8-hourly. By the <!ighln day the serum magnesium level had risen from 1.6mg/dllo 4.2mg/dl (normal 1.8-2.4mg/dll. The antacid was changed \0

one containing no magnesium. and 3 days later the serum magnesium level was down to 2.5mg/dL Serum calcium rose rrom 6. 9mg/ dlw I I. Omg/ dl over the total II days of antacid therapy. Magnesium absorption may have been enhanced by the decrea.~ed GI motility in the sick. pancuronium-paralysed irlfant and by (he reduced ellcreling ability of neonates. Hurnrhrc~·. ~1. c1 i:l' , .inurmlt on),t:'dii.Hric~ 9~: .l1.1lh.:-h I<)~ I)

0157 ·7271/8 I /0320·0003/0$00.50/0 tl ADIS Press Reactions 20 Mar 1981 3