Reactions 1130 - 2 Dec 2006

Atorvastatin/fluvastatin

Muscle pain and allergic-toxic hepatitis: 2 casereports

One patient developed muscle pain during treatment withatorvastatin and another patient developed allergic-toxichepatitis during treatment with fluvastatin.

A patient [age and sex not stated], who received atorvastatin[dosage not stated] for hyperlipidaemia, developed pain inboth shoulders, arms and thighs and an elevated erythrocytesedimentation rate (ESR) on two different occasions [durationof treatment before reaction onset not stated]. Polymyalgiarheumatica was suspected and, both times, the patient’ssymptoms and ESR improved during cortisone therapy. It waslater revealed that the pain was induced by atorvastatin.[Patient outcome not stated].

A 75-year-old woman developed a fever of 39.8°C thatlasted for several days, pruritus and eosinophilia of 9.2%during the days immediately following treatment withfluvastatin 40mg [therapeutic indication and frequency notstated]. She also had hyperbilirubinuria, acholia, andtransaminase-, alkaline phosphatase- and γ-glutamyltransferase-elevations. Allergic-toxic statin-induced hepatitiswas diagnosed. [Treatment and patient outcome not stated].Fuhrmann W. Persistent CK increase after CSE-inhibitor therapy. DeutscheMedizinische Wochenschrift 131: 2176, No. 39, 29 Sep 2006 [German;summarised from a translation] - Germany 801045915

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Reactions 2 Dec 2006 No. 11300114-9954/10/1130-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved