catumaxomab
TRANSCRIPT
Reactions 1501, p13 - 17 May 2014
Catumaxomab
Fever, nausea and vomiting: case reportA 69-year-old woman developed fever, nausea and vomiting
while receiving intraperitoneal catumaxomab [dose not stated]as a part of a study.
The woman underwent left mastectomy and ipsilateralaxillary lymph node dissection for invasive ductal carcinomagrade 2 in 1995. She subsequently received several lines oftreatment, however she was diagnosed with ascites inNovember 2009 and underwent evacuative paracentasis inDecember 2009. In February 2010 she was hospitalised for thetreatment of malignant ascites and received 3-hourintraperitoneal catumaxomab infusions on February 2, 5, 9 and12. She developed grade 1 fever, nausea and vomiting [time toreaction not stated].
The woman was treated with metoclopramide, ondansetronand paracetamol and her symptoms were well controlled. Sheshowed partial regression of liver metastases and received asecond course of intraperitoneal catumaxomab with no furtherbenefit. She was started with capecitabine, however, she tookit only for 2 weeks and died on 28th December 2010.
Author comment: "Catumaxomab was well tolerated,with mild adverse events controlled with appropriatesupportive therapy."Petrelli F, et al. Regression of liver metastases after treatment with intraperitonealcatumaxomab for malignant ascites due to breast cancer. Targeted Oncology 8:291-294, No. 4, Dec 2013. Available from: URL: http://doi.org/10.1007/s11523-012-0240-y - Italy 803103237
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