Reactions 1173 - 13 Oct 2007

Citalopram

Mania: case reportA 43-year-old man developed mania following

administration of citalopram for interferon-induceddepression.

The man, who was receiving peginterferon-α-2b for chronichepatitis C, developed significant depressive symptoms. Atweek 6 of interferon therapy, he started receiving citalopram10 mg/day, which was increased 1 week later to 20 mg/day. Atweek 14 of interferon therapy, after 8 weeks of citalopramtherapy, he developed an elevated mood and citalopram wasdiscontinued. At week 16 of interferon treatment, hedeveloped a manic episode with flight of ideas, pressuredspeech, a decreased need for sleep, increased goal directedbehaviours and inflated self esteem.

The man received haloperidol, but his manic symptomspersisted for the remaining course of interferon treatment. Atweek 24 of interferon treatment, interferon was discontinued.Haloperidol was replaced by oxcarbazepine and he receivedsupportive psychotherapy. Within 4 weeks, his manicsymptoms abated.

Author comment: "Here, we present a patient whodeveloped a severe manic episode after the administration ofantidepressant therapy for IFN [interferon]-induceddepression while the dosage of IFN-α remained fixed."Wu P-L, et al. Manic episode associated with citalopram therapy for interferon-induced depression in a patient with chronic hepatitis C infection. General HospitalPsychiatry 29: 374-376, No. 4, Jul-Aug 2007 - Taiwan 801091734

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Reactions 13 Oct 2007 No. 11730114-9954/10/1173-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved