Reactions 1250 - 2 May 2009

SCitalopram

Inappropriate antidiuretic hormone secretion inan elderly patient: case report

A 96-year-old woman had been receiving citalopram20 mg/day [therapeutic indication not stated] for 2 dayswhen she was admitted with a 24-hour history ofdeveloping asthenia, anorexia, bradypsychia, drowsinessand dizziness. Her plasma sodium level was 117 mmol/Land her plasma osmolality was 249 mOsm/kg. Citalopram-induced inappropriate vasopressin secretion wassuspected, and the agent was discontinued. She wastreated with isotonic saline and restricted water intake, andher symptoms improved. She was asymptomatic atdischarge with a plasma sodium level of 135 mmol/L,which remained normal at follow-up 1 month later.Franco Hidalgo S, et al. Citalopram and inadequate secretion of vasopressin.Endocrinologia y Nutricion 56: 47-48, No. 1, Jan 2009 [Spanish: summarised froma translation] - Spain 801126602

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Reactions 2 May 2009 No. 12500114-9954/10/1250-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved