Reactions 1366 - 27 Aug 2011

SCitalopram

Seizures: case reportA 50-year-old woman, who had a history of major

depressive disorder, presented to the emergencydepartment in October 2010 after developing twogeneralised tonic-clonic seizures on 2 consecutive days.She showed confusion upon presentation. Oral citalopram20 mg/day [frequency of administration not stated] hadbeen initiated 4 days before the first seizure. She wasadmitted for observation for 4 days in the general medicalward. Citalopram was discontinued upon admission; shehad no further seizures during her stay in the hospital andduring a 1-month follow-up period.

Author comment: "[T]his is the first report to documentthat citalopram may induce seizures at low doses, even in apatient who had tolerated another SSRI (selective serotoninreuptake inhibitor) in the past."Iskandar JW, et al. Citalopram-induced seizures in a healthy adult taking an FDA-approved dosage: A case report. Primary Care Companion to the Journal ofClinical Psychiatry 13: e1, No. 3, 2011. Available from: URL: http://dx.doi.org/10.4088/pcc.10l01113 - USA 803059340

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Reactions 27 Aug 2011 No. 13660114-9954/10/1366-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved