Reactions 592 - 16 Mar 1996

★Citalopram

First report of anorgasmia: case reportThe following report describes a case of citalopram-induced

anorgasmia that was treated successfully with cyproheptadine.A 47-year-old man was treated with citalopram 60 mg/day

[duration of therapy not stated] for depression. Following thestart of therapy, he experienced anorgasmia. When the dosageof citalopram was decreased to 40 mg/day anorgasmiaimproved, but his depressive symptoms started to re-emerge.

Initially, the man was treated with cyproheptadine 2mg, butno effect on anorgasmia was noted. He was then givencyproheptadine 4mg the evening prior to intercourse, and hisanorgasmia resolved. He did not experience any adverseeffects over a 6-month period. He decided to stop takingcitalopram and his depressive symptoms recurred. He wasthen treated with fluoxetine and he subsequently experiencedsome delay in ejaculation.

Author comment: ‘Medline search up to May 1995 did notresult in any information concerning citalopram-induced sexualside effects.’Lauerma H. Successful treatment of citalopram-induced anorgasmia bycyproheptadine. Acta Psychiatrica Scandinavica 93: 69-70, Jan 1996 -Finland 800427024

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Reactions 16 Mar 1996 No. 5920114-9954/10/0592-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved