Reactions 1374 - 22 Oct 2011

SDexamethasone/lenalidomide/pravastatin

Rhabdomyolysis in an elderly patient: casereport

A 77-year-old man developed rhabdomyolysis whilereceiving dexamethasone, lenalidomide and pravastatin[dosage and route information incomplete].

The man, who was diagnosed with multiple myeloma in2007, began oral lenalidomide 25mg daily, plusdexamethasone on 8 November 2010. His history alsoincluded hypercholesterolaemia, for which he had receivedpravastatin since February 2009. On 13 November 2010,he developed sudden muscle pain in his upper arms, aswell as fever, extremity weakness and an inability to walk.Following admission, tests revealed an elevated creatinekinase level, slightly impaired renal function andmyoglobinuria. Rhabdomyolysis was diagnosed.

Lenalidomide and pravastatin were withdrawn, and theman received hydration. On hospital day 2, his creatinekinase increased to 16 126 IU/L and he experienced musclepain in his thighs; however, his symptoms subsequentlyregressed. By day 10, his laboratory values normalised andhis muscle symptoms resolved. On day 36, he wasdischarged.Urata C, et al. Lenalidomide in combination with dexamethasone inducedrhabdomyolysis in a multiple myeloma patient treated with pravastatin.International Journal of Hematology 94: 216-217, No. 2, Aug 2011. Availablefrom: URL: http://dx.doi.org/10.1007/s12185-011-0903-y - Japan 803061767

1

Reactions 22 Oct 2011 No. 13740114-9954/10/1374-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved