Reactions 1497, p23 - 19 Apr 2014

Imipramine

Hyperpigmentation: case reportA 63-year-old woman developed hyperpigmentation

following treatment with imipramine [therapeutic indicationnot stated]. After receiving imipramine for more than 20 years,the woman developed a bluish-brown discolouration on herneck and face [route and dosage not stated]. Histologyrevealed numerous interstitial and perivascular brownglobules, composed of melanin, in the dermis. She wasdiagnosed with imipramine-induced hyperpigmentation basedon these findings. [Treatment and outcome not stated].

Author comment: "A diagnosis of imipramine-inducedhyperpigmentation was made based on the histopathologyand clinical history."McFaddin C, et al. Imipramine-induced hyperpigmentation. Journal of theAmerican Academy of Dermatology 70 (Suppl. 1): AB151 abstr. P8073, No. 5,May 2014 - USA 803102013

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Reactions 19 Apr 2014 No. 14970114-9954/14/1497-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved