Reactions 1510, p29 - 19 Jul 2014

SMepivacaine

Type I hypersensitivity: case reportA 54-year-old woman who received mepivacaine developed

type I hypersensitivity.The woman presented after developing facial swelling,

throat discomfort, dizziness and severe cutaneous itchingimmediately after receiving local anaesthesia withmepivacaine [route, dosage and outcome not stated]. She haddeveloped facial angioedema after local anaesthesia 37 yearsearlier. Allergies to lidocaine and procaine had been confirmedin 2009, 3 years before the current presentation; however,allergy to mepivacaine, articaine and bupivacaine had beenruled out.

Skin prick testing was positive for procaine, lidocaine andmepivacaine, and negative for bupivacaine and articaine.Basophil activation testing was positive for mepivacaine, andnegative for bupivacaine and articaine.

Author comment: "Although type I hypersensitivityreactions to amide-type local anaesthesics are rare, little isknown about crossreactivity among these drugs. We present acase report with confirmed allergy, by in vivo and in vitrotests, to Mepivacaine and cross reactivity in vivo to Procaineand Lidocaine."Lizarza S, et al. Local anaesthetics allergy: A case report. Allergy 68 (Suppl. 97):391 abstr. 1068, Sep 2013. Available from: URL: http://doi.org/10.1111/all.12251[abstract] - Spain 803105935

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Reactions 19 Jul 2014 No. 15100114-9954/14/1510-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved