Reactions 823 - 14 Oct 2000

★ SNaratriptan

First report of variant angina pectoris: case reportVariant angina pectoris was associated with naratriptan

therapy for cluster headache in a 34-year-old man withcardiovascular disease risk factors, including a history ofsmoking, dyslipidaemia and a familial history of cardiovasculardisease.

One day after the man commenced therapy with naratriptan[dosage not stated] and metoprolol, he was hospitalised withsuspected unstable angina pectoris. During an examination hehad chest pain. An ECG was consistent with typical variantangina. At follow-up 6 months later, he was asymptomatic.Allal J, et al. First case of documented variant angina induced by a treatment bynaratriptan. 7th World Conference on Clinical Pharmacology and Therapeutics(CPT) and the 4th Congress of the European Association for ClinicalPharmacology and Therapeutics (EACPT) : 175, 15 Jul 2000 [abstract] -France 800843526

» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of variant angina pectorisassociated with naratriptan.

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Reactions 14 Oct 2000 No. 8230114-9954/10/0823-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved