Reactions 1371 - 1 Oct 2011

SPramipexole/ropinirole

Compulsive disorders: 3 case reportsA woman and two men aged 61–72 years developed a

compulsion to sing after starting pramipexole or ropinirole[routes and outcomes not stated] for Parkinson’s disease(PD).

A 61-year-old man with a 5-year history of PD startedlow-dose therapy with pramipexole at 0.18mg three timesdaily. Four weeks later he presented complaining of ’greatdiscomfort’ that was relieved by singing.

The remaining two patients aged 72 and 65 years,respectively, had recently been diagnosed with PD. Theman initially received levodopa, which was stopped due toadverse effects. Pramipexole was started and slowlytitrated. While receiving 2.1 mg/day he developed acompulsive need to sing [time to reaction onset not stated].Two weeks after starting extended-release ropinirole 4mg[frequency not stated], the 65-year-old woman presentedcomplaining of compulsive singing; punding andhypomania were noted.Borrue-Fernandez C. Compulsive Singing as and Impulse Control Disorder inDopamine Agonist Treated Patients: Review of Three Cases. 15th Congress of theEuropean Federation of Neurological Societies : abstr. P2432, 10 Sep 2011.Available from: URL: http://efns2011.efns.org - Spain 803060936

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Reactions 1 Oct 2011 No. 13710114-9954/10/1371-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved