Reactions 1426 - 3 Nov 2012

★Pramipexole/ropinirole

First report of spontaneous unwelcome orgasms:case report

A 52-year-old woman developed spontaneousunwelcome orgasms while receiving pramipexole andropinirole for multifocal dystonia.

The woman initially received levodopa, but treatmenthad to be stopped because of severe diarrhoea, orthostatichypotension, and weight loss. She subsequently startedpramipexole 0.088mg twice daily [route not stated], and onthe third day, she experienced four spontaneous orgasms.Each occurred about 1 hour after taking pramipexole, threeduring the day while doing housework, and one at night,causing her to wake up. The orgasms happened withoutpremonition, increased sexual desire, or perceivablestimulation. She considered them as undesired and greatlyembarrassing.

Pramipexole was withdrawn, and the woman did notexperience any further undesired orgasms. Ropinirole wasstarted 10 weeks later. At a ropinirole dosage of 0.5 mg/day[route and time to reaction onset not stated], thespontaneous orgasms recurred, ceasing again at a dosageof 0.25 mg/day.

Author comment: "A patient with dopa-responsivedystonia experienced spontaneous unwelcome orgasms frompramipexole and ropinirole without hypersexual behavior orincreased libido."Kaut O, et al. Spontaneous unwelcome orgasms due to pramipexole and ropinirole.Movement Disorders 27: 1327-1328, No. 10, Sep 2012. Available from: URL:http://dx.doi.org/10.1002/mds.25134 - Germany 803079214

» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports ofspontaneous orgasm associated with pramipexole orropinirole. The WHO ADR database 3 reports of abnormalorgasm associated with pramipexole, and no reports forropinirole.

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Reactions 3 Nov 2012 No. 14260114-9954/10/1426-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved