Reactions 1423 - 13 Oct 2012

Prasugrel

Rash: case reportA 59-year-old man developed a rash during treatment

with prasugrel. The man, who had a history of diabetes andunstable angina, underwent placement of a drug-elutingstent. Then he was started on prasugrel [dosage and routenot stated], which was added to his aspirin. Five days later,he developed a full-body rash. The rash was diffuse,pruritic, exanthematous and maculopapular. It spared hismucous membranes. Results of his histologicalexamination were consistent with a hypersensitivityreaction. The patient was switched from prasugrel toclopidogrel. The rash subsided and did not recur withclopidogrel therapy.

Author comment: "Using the Naranjo probability scale,we determined that this drug reaction was indicative of aprobable event."Deshmukh AJ, et al. Prasugrel-induced rash. Annals of Pharmacotherapy 46:1123-1125, No. 7-8, Jul-Aug 2012. Available from: URL: http://dx.doi.org/10.1345/aph.1R062 - USA 803078318

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Reactions 13 Oct 2012 No. 14230114-9954/10/1423-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved