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Quinapril: a new ACE inhibitor to be launched in the USA later this year

Therapeutic use Quinapril. A review of its pharmacological

properties. and therapeutic efficacy in cardiovascular disorders. Wadworth AN. Brogden RN. Drugs 41: 378-399. Mar 1991

A single-blind comparison of the efficacy and tolerability of lisinopril and quinapril in the treatment of essential hypertension. De Cesaris R. et al. Acta Therapeutica 17: 69-78. No.1. 1991

Use of quinapril in the elderly patient Schnaper HW. American Journal of Hypertension 3: 278S-282S. Nov 1990

Quinapril in chronic heart failure. Northridge DB. Dargie HJ. American Journal of Hypertension 3: 283S-287S. Nov 1990

Effects of the converting enzyme inhibitor quinapril on the circadian rhythm of blood pressure and heart rate in essential hypertension. Portaluppi F. et al. Current Therapeutic Research 48: 613-622. Oct 1990

Long-term efficacy and safety of quinapril in treatment of hypertension: an interim report. Smith LK. et al. Chest 98 (Suppl.): 17. Aug 1990

A comparison of once-daily antihypertensive therapy with quinapril and lisinopril. De Cesaris R. et al. Minerva Medica 81: 541-546. Jul-Aug 1990

Digoxin. converting-enzyme inhibition (quinapril). and the combination in patients with congestive heart failure functional class II and sinus rhythm. Kromer EP. et al. Journal of Cardiovascular Pharmacology 16: 9-14. Jul 1990

Overview of the clinical development of quinapril. Frank GJ. Clinical Cardiology 13 (Suppl. 7): 13-18. Jun 1990

The safety and efficacy of quinapril in the treatment of mild to moderate essential hypertension. Frishman WHo Clinical Cardiology 13 (Suppl. 7): 19-25. Jun 1990. Summary in 3 parts.

The efficacy and safety of quinapril in the treatment of moderate to severe and severe hypertension: comparison to captopril. Frishman WHo Clinical Cardiology 13 (Suppl. 7): 26-31. Jun 1990

ACE inhibitors in the treatment of heart failure. DiBianco R. Clinical Cardiology i3 (Suppl. 7): 32-38, Jun 1990

ACE inhibitors in the treatment of hypertension in the older patient Canter D, Frank G. European Heart Journal II (Suppl. D): 33-43. May 1990

ACE inhibitors in mild heart failure: first-line or second-line therapy? Cleland JGF. European Heart Journal II (Suppl. D): 53-57. May 1990

Quinapril versus captopril twice daily as initial monotherapy in severe hypertension.

8 I •• 1991 INPHARMAe

Frishman WHo American Journal of Hypertension 3: lOOA. May 1990

Overview of quinapril. a new ACE inhibitor. Frank GJ. et al. Journal of Cardiovascular Pharmacology 15 (Suppl. 2): 14-23. 1990

The safety and tolerability of quinapril. Knapp LE. et al. Journal of Cardiovascular Pharmacology 15 (Suppl. 2): 47-55. 1990

Worldwide clinical experience with ACE inhibitors. The role of quinapril. Summary. Dzau VJ. Journal of Cardiovascular Pharmacology 15 (Suppl. 2): 62-63. 1990

Digoxin. ACE-inhibition (quinapril) or the combination of both drugs for the treatment of mild cardiac insufficiency (NYHA II) in patients with sinus rhythm? Kromer EP. et al. Klinische Wochenschrift 68 (suppl. 19): 265. 1990

Pharmacokinetics Pharmacokinetics of quinapril and its active

metabolite quinaprilat during continuous ambulatory peritoneal dialysis. Swartz RD, et al. Journal of Clinical Pharmacology 30: 1136-1141. Dec 1990

Pharmacokinetics of quinapril and its active metabolite. quinaprilat, in patients on chronic hemodialysis. Blum RA. et al. Journal of Clinical Pharmacology 30: 938-942, Oct 1990

Clinical pharmacokinetics of the newer ACE inhibitors. A review. Kelly JG. O'Malley K. Clinical Pharmacokinetics 19: 177-196, Sep 1990

Pharmacokinetics of quinapril HCI and its active metabolite. quinaprilat, in patients with end-stage renal disease on continuous ambulatory peritoneal dialysis. Posvar EL, et al. Journal of Clinical Pharmacology 30: 834, Sep 1990

Pharmacokinetics of quinapril HCl and its active metabolite, quinaprilat. in patients with end-stage renal disease on chronic hemodialysis. Blum RA, et al. Journal of Clinical Pharmacology 30: 841, Sep 1990

Intestinal absorption mechanism of three angiotensin-converting enzyme inhibitors: quinapril. benazepril and CGS16617. Vee S, Amidon GL. Pharmaceutical Research 7 (Suppl.): 155. Sep 1990

Effective accumulation half-life for quinaprilat following oral quinapril dosing. Olson SC, et al. Pharmaceutical Research 7 (Suppl.): 209, Sep 1990

The pharmacokinetics and pharmacodynamics of quinapril and quinaprilat in renal impairment Begg EJ, et al. British Journal of Clinical Pharmacology 30: 213-220, Aug 1990

Metabolism and pharmacokinetic profile of quinapril: a new nonsulfhydryl angiotensin­converting enzyme inhibitor. Melby Jc. Cardiovascular Reviews and Reports II: 21-25, Jul 1990

Quinapril: overview of preclinical data. Kaplan HR. et al. Clinical Cardiology 13 (Suppl. 7): 6-12,Jun 1990

Pharmacodynamics Acute stimulation of renin secretion changes the

multiple form profile of active plasma renin. Opsahl JA, et al. American Journal of Hypertension 4: 126-130. Feb 1991

Endothelin. vasoconstriction. and endothelial damage in Raynaud's phenomenon. Cimminiello C. et al. Lancet 337: 114-115. 12 Jan 1991

Platelet function during antihypertensive treatment with quinapril. a novel angiotensin converting enzyme inhibitor. Gupta RK. et al. Journal of Cardiovascular Pharmacology 17: 13-19. Jan 1991

Dissociation of changes in cardiovascular mass and performance with angiotensin­converting enzyme inhibitors in Wistar­Kyoto and spontaneously hypertensive rats. Frohlich ED. Sasaki O. Journal of the American College of Cardiology 16: 1492-1499.15 Nov 1990

Evaluation of quinapril on regional blood flow and cardiac function in patients with congestive heart failure. Munger MA. et al. Journal of Clinical Pharmacology 30: 833, Sep 1990

Hemodynamic effects of quinapril. a novel angiotensin-converting enzyme inhibitor. Gupta RK, et al. Clinical Pharmacology and Therapeutics 48: 41-49, Jul 1990

Quinapril reduces arterial blood pressure and improves metabolic control in elderly hypertensive diabetic patients. Paolisso G. et al. Diabete et Metabolisme 16: 264-265, May-Jun 1990

Effects of single doses of quinapril and atenolol on autonomic nervous function and exercise capacity in healthy volunteers. Porsti I, et al. European Journal of Clinical Pharmacology 38: 541-546, Jun 1990

The effects of quinapril, a new angiotensin converting enzyme inhibitor, on the temporal progression of left ventricular failure in the cardiomyopathic hamster. Haleen SJ. et al. American Journal of Hypertension 3: I09A. May 1990

Hemodynamic effects of quinapril, a novel angiotensin converting enzyme inhibitor. Kjeldsen SE. et al. American Journal of Hypertension 3: 119A, May 1990

Effects of quinapril on the renal and iliac vasculature. Bjork F, et al. Faseb Journal 4: 439, 26 Feb 1990

Inhibition of angiotensin-converting enzyme (ACE) in plasma and tissue. Fabris B, et al. Journal of Cardiovascular Pharmacology 15 (Suppl. 2): 6- I 3. 1990

The hemodynamic effects of ACE inhibitors in the treatment of congesti ve heart failure. Nieminen MS, Kupari M. Journal of Cardiovascular Pharmacology 15 (Suppl. 2): 36-40. 1990

The effects of ACE inhibitors on exercise capacity in the treatment of congestive heart failure. Riegger GAl. Journal of Cardiovascular Pharmacology 15 (Suppl. 2): 41-46. 1990

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