Reactions 1415 - 18 Aug 2012

SRopinirole

Delirium and paraphasia in an elderly patient:case report

A 76-year-old man developed delirium and paraphasiawhile receiving ropinirole.

The man, who had been admitted with herpesencephalitis, developed apathy and depression. He startedreceiving oral ropinirole 0.25 mg/day on hospital day 62.On day 71, his apathy improved, and ropinirole wasincreased to 0.75 mg/day. On day 72, he became deliriousand paraphasic during the night, crying out in a loud voiceand speaking nonsense words. He also became violent andrude.

Ropinirole was reduced to 0.25 mg/day on day 73, andthe man’s delirium and paraphasia subsequentlydisappeared. Ropinirole was further reduced to0.125 mg/day as his mental state stabilised, and waswithdrawn on day 127.

Author comment: "Our patient responded to ropinirolewithin 10 days and reached his maximum improvement atabout 3 weeks. His side effects of delirium and paraphasiadisappeared soon after we lowered his dose."Kohno N, et al. The effect of ropinirole on apathy and depression after herpesencephalitis. Cognitive and Behavioral Neurology 25: 98-102, No. 2, Jun 2012.Available from: URL: http://dx.doi.org/10.1097/WNN.0b013e3182591ea5 -Japan 803075444

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Reactions 18 Aug 2012 No. 14150114-9954/10/1415-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved