Reactions 1386 - 28 Jan 2012

Catumaxomab

Various toxicities following intrapleuraladministration: 2 case reports

A 53-year-old woman with breast cancer and a 68-year-old man with lung cancer received two doses ofcatumaxomab intrapleurally, 10µg on day 1 followed by20µg on day 4, for malignant pleural effusion. Systemicmedications were administered if required, including non-steroids for chills or fever. The catheter was removedimmediately following the last infusion. They exhibited anintensive acute general response with fever, chills, and asteep elevation of inflammatory markers [times to reactiononset not stated]; one patient also displayed erythema ofthe skin beneath the chest tube, possibly due to a leakageinto the thoracic wall. All the side effects resolved within afew days. The woman died of progressive disease 3 monthslater.Schneider C-P, et al. Catumaxomab (CAT) in patients with malignant pleuraleffusion (MPE). 2 case reports. Onkologie 34 (Suppl. 6): 38 abstr. P183, Sep 2011.Available from: URL: http://dx.doi.org/10.1159/000333299 - Germany 803066168

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Reactions 28 Jan 2012 No. 13860114-9954/10/1386-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved