Reactions 1371 - 1 Oct 2011

Clomipramine

Galactorrhoea: case reportA 35-year-old woman with a history of anxiety,

hypervigilance, low mood, sleep disturbance and somaticobsessions started receiving clomipramine 75 mg/day[route not stated]. Two months later, she presented withpersistent mood symptoms and a 1-week history ofgalactorrhoea from both breasts. She reported a similarepisode of galactorrhoea with amisulpride therapy 4 yearsearlier, which had resolved after stopping amisulpride. Shewas diagnosed with recurrent major depressive disorderand obsessive compulsive disorder. Clomipramine waschanged to escitalopram. After 2 weeks, her galactorrhoeahad resolved.

Author comment: "[G]alactorrhea was attributed toclomipramine treatment as the most probable reason."Ertekin BA, et al. Galactorrhea induced by clomipramine: a case report. 24thAnnual Congress of the European College of Neuropsychopharmacology : abstr.P.2.c.019, 3 Sep 2011. Available from: URL: http://link.adisinsight.com/q2PGg -Turkey 803060767

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Reactions 1 Oct 2011 No. 13710114-9954/10/1371-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved