Reactions 1376 - 5 Nov 2011

Ergocalciferol

Vitamin D toxicity: case reportA 35-year-old woman, who had undergone surgery for

thyroid cancer at age 19 years, developed postoperativehypoparathyroidism secondary to persistenthypocalcaemia, and was treated with ergocalciferol[vitamin D2; Drisdol; route not stated] in alternating dosesof 50 000 and 100 000IU daily, and calcium carbonate.

She presented with a history of polyuria, polydypsia,limb numbness, muscle pain, weight loss and constipationover the last year [duration of treatment to reaction onsetnot clearly stated]. Laboratory investigations revealedcalcium and 25(OH)vitamin D levels of 8.9 mg/dL and284 ng/mL, respectively.

Ergocalciferol was discontinued and, after a month, hersymptoms resolved and her 25(OH)vitamin D level haddecreased to 87 ng/mL.Kim C, et al. Vitamin D Toxicity in a Patient with Surgical Hypoparathyroidism.33rd Annual Meeting of the American Society for Bone and Mineral Research :abstr. MO0175, 16 Sep 2011. Available from: URL: http://www.asbmr.org -USA 803062328

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Reactions 5 Nov 2011 No. 13760114-9954/10/1376-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved