Reactions 1447 - 13 Apr 2013

SImipramine

Dystonia in a child: case reportAn 8-year-old boy developed dystonia while receiving

imipramine for major depression.The boy was diagnosed with a major depressive episode,

and started on imipramine 25 mg/day [route not stated]. Threemonths later, he presented with involuntary dystonicmovements characterised by sideways turning of the neck,twisted facial muscles and mouth opening. He reported nourge to perform these movements, which were painful andsignificantly interfered with basic activities, such as eating anddrinking. Imipramine was his only medication, and a diagnosisof transient drug-induced dystonia was made. Imipramine wasimmediately withdrawn. The dystonia persisted for more than2 days after the last imipramine intake; he remained free ofabnormal movements over 1 year of follow-up.

Author comment: "The case described in this reportrepresents a rare consequence of a tricyclic antidepressant".Freitas FAC, et al. Imipramine-induced dystonia in a child: A case report. RevistaBrasileira de Psiquiatria 34: 497-500, No. 4, Dec 2012. Available from: URL:http://dx.doi.org/10.1016/j.rbp.2012.04.005 - Brazil 803085515

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Reactions 13 Apr 2013 No. 14470114-9954/10/1447-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved