Imipramine First report of hypertension: case report *

Treatment with melphalan , cyclophosphamide (,Cytoxan '), Vi nCristine. dacarbazlne [DITC Imidazole carboxamide) , doxorublcln [adrlamycln) , cisplatin [cisplatlnium) and tenlposide [VM-26] was initiated In a 4-year-old girl with stage IV neuroblas toma After 13 months ' treatment BP was 96/ 66mm Hg. Imipramine 25mg was given for panic attacks and 4 hours later the patient had a headache, severe emesIs and BP rose from 140/ 118 to 190/ 160mm Hg.

BP normalised following Imipramine withdrawal and treatment with furosemide [frusemide) 10mg No further hypertension was noted dUring the course of treatment .

Although the patient received other medications at the time of the hypertensive CriSIS ' ... none of these could be incriminated as the cause of hypertension' Indicating Imipramine as the causative factor

Feusner J OLeary M. Beach B American Journal of Pedlalrlc Hemalology/Oncology 94 305307 No 4 1987

Depression following substitution from a generic to a brand name product: case report Gardos G A case of therapeutic meqUivalence of a brand name drug Journal of Clinical Psychopharmacology 7 44 I Dec t 987

0157-7271 / 88/ 0227-0007/ 0$01.00/ 0 © ADIS Press REACTIONS · 27 February 1988 7