Reactions 1318 - 11 Sep 2010

Pramipexole/ropinirole

Hiccups: case reportA 62-year-old man started treatment with oral

pramipexole 0.18mg three times daily for Parkinson’sdisease. A few days later, he developed hiccups whichincreased over the next days, and mild nausea whichpersisted for 10 days, even after discontinuing the drug. Hewas changed to ropinirole 2mg daily [route not stated], buthiccups immediately recurred. Ropinirole wasdiscontinued, and no therapy was successful in treating thehiccups which lasted 1 week. Rasagiline and levodopa/carbidopa were started, with no side-effects seen. He washiccup-free at follow-up after 9 months.

Author comment: "In this case, a strict relationshipbetween hiccups and [dopamine agonists] intake seems likelyas hiccups disappeared after drugs were stopped."Moja MC. Hiccups associated with non-ergoline dopamine agonists in Parkinson’sdisease. Movement Disorders 25: 1292, No. 9, 15 Jul 2010. Available from: URL:http://dx.doi.org/10.1002/mds.23056 - Italy 803037416

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Reactions 11 Sep 2010 No. 13180114-9954/10/1318-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved