Reactions 743 - 20 Mar 1999

★Riluzole

First report of kidney disorders: case reportKidney disorders occurred in a 44-year-old man during

treatment with riluzole for amyotrophic lateral sclerosis.The man started treatment with riluzole 100 mg/day. Three

months later, tests showed polydypsia, polyuria,normoglycaemic glycosuria, hypercalciuria (513.4 mg/24h)and hyperuricuria (1030.6 mg/24h). Renal impairment due toriluzole was suspected and the agent was discontinued. Onemonth later, the man’s renal function had recovered.

Author comment: In this patient, other causes of renaldamage, apart from riluzole therapy, were excluded. ‘Wepropose that urine analysis should be added to routinemonitoring of liver enzymes and blood cell count in ALS[amyotrophic lateral sclerosis] patients treated with riluzole.’Poloni TE, et al. Renal tubular impairment during riluzole therapy. Neurology 52:670, Feb 1999 - Italy 800745654

» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of kidney disordersassociated with riluzole.

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Reactions 20 Mar 1999 No. 7430114-9954/10/0743-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved