Reactions 1158 - 30 Jun 2007

★ ORopinirole overdose

Various toxicities (first report of lymphopenia)following intentional administration in an elderlypatient: case report

A 65-year-old man, who had been receiving ropinirole 20mgonce daily for 7 years for Parkinson’s disease, presented5 hours after ingesting 22 tablets of ropinirole 5mg at a singlego. On presentation, he had abdominal pain, nausea, left-legdyskinesia and epigastric tenderness. CNS examinationshowed brisk deep tendon jerks bilaterally. Laboratoryinvestigations showed lymphopenia (0.64%) and neutrophilia(8.74%) with a WBC count of 9.6. Within 8 hours of ingestion,his symptoms subsided and he was sent home [patienttreatment not clearly stated].

Author comment: "Increase in the neutrophil/lymphocyteratio may have been due to [ropinirole]."Ahmed I. A case report of a deliberate overdose of ropinirole Movement Disorders22 (Suppl. 16): 91 abstr. 296, Jun 2007 [abstract] - United Kingdom 801079111

» Editorial comment: A search of AdisBase, Medline and theWHO Adverse Drug Reactions database did not reveal anyprevious case reports of lymphopenia associated with ropinirole.

1

Reactions 30 Jun 2007 No. 11580114-9954/10/1158-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved