289338320-ppt-dislipidemia
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DISLIPIDEMIAZulfa Vinanta
1102011302
REFERAT
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LIPID dan LIPOPROTEIN
Jenis li!"!tein
#il!$i%"!n
#il!$i%"!n $e$&a'a $a%anan %e (a"in)an le$a% dan !t!t "an)%a se"ta$e$&a'a %!leste"!l %e$&ali %e *ea"+
VLDLVLDL di)una%an untu% $en)an)%utt"i)lise"ida %e (a"in)an
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IDL
IDL $e"ua%an ,at e"anta"a se'a%tuVLDL di%ata&!lis$e $en(adi IDL+
LDL
Li!"!tein en)an)%ut %!leste"!l
te"&esa" -.0/+ id"!lisis LDL$en)*asil%an %!leste"!l &e&as an)&e"fun)si untu% sintesis sel $e$&"andan *!"$!ne ste"!id+
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DL
DL an) $e"ua%an inverse predictor untu% "esi%!ena%it (antun) %!"!ne"+ #ada" DL $enu"un ada%e)e$u%an e"!%!% asien dia&etes an) tida%
te"%!nt"!l dan e$a%ai %!$&inasi est"!)en4"!)estin+DL $e$ili%i efe% "!te%tif aitu $en)an)%ut%!leste"!l da"i e"ife" untu% di $eta&!lis$e di *ea"
Li!"!tein -a Te"di"i atas a"ti%el LDL dan a!"!tein se%unde"selain a!54100+ Li!"!tein (enis ini $en)*a$&at6&"in!lisis atau &e"sifat ate"!)eni%+
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Jalu" e%s!)en
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Jalu" end!)en
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Jalu" "e7e"se 8*!leste"!l t"ans!"t
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De6nisi Disliide$ia
Disliide$ia suatu %elainan an)te"(adi ada $eta&!lis$e li!"!tein&ai% itu &e"le&i*an atauun %e%u"an)an+
#eadaan an) $un)%in ti$&ul daat&e"ua enin)%atan da"i %ada" %!leste"!lt!tal %ada" l!' densit li!"!tein -LDLdan %ada" t"i)lise"ida se"ta enu"unanda"i %ada" *i)* densit li!"!tein -DLdi dala$ da"a*
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Faktor Resiko
Ri'aat %elua")a den)an *ie"liide$ia
O&esitas
Diet %aa le$a%
#u"an) $ela%u%an !la* "a)a Penala*)unaan al%!*!l
Me"!%!% si)a"et
Dia&etes an) tida% te"%!nt"!l den)an &ai% i!ti"!idis$e
Si"!sis
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#lasi6%asi
#lasi6%asi Fen!tii%
a+ #lasi6%asi EAS -Eu"!eanAt*e"!sele"!sis S!8iet+
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&+ #lasi6%asi N9EP -Nati!nal 9*!leste"!lEdu8ati!n P"!)"a$+
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8+ #lasi6%asi :O -:!"ld ealt*O")ani,ati!n+
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#lasi6%asi Pat!)eni%
1+ P"i$e" Disliid$ia "i$e" $e$ili%iene&a& an) tida% (elas+ 9!nt!* da"i
disliide$ia "i$e" adala**ie"%!leste"!le$ia !li)eni%*ie"%!leste"!le$ia fa$ilial *ie"liide$ia%!$&inasi fa$ilial dan lain4lain+
2+ Se%unde" Disliide$ia se%unde"$e$ili%i ena%it dasa" see"ti sind"!$anef"!ti% dia&etes $elitus *i!ti"!idis$e+
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Gejala Klinis
#e&ana%an asien adala* asi$t!$ati%sela$a &e"ta*un4ta*un se&elu$ena%it (elas se8a"a %linis+
;e(ala4)e(ala an) &isa ta$a%dianta"ana &e"%e"in)at (antun)
&e"de&a" nafas ende% dan 8e$as+
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Diagnosis
Pada ana$nesis &iasana didaat%an fa%t!""esi%! see"ti %e)e$u%an diabetes mellitus,
%!nsu$si tin))i le$a% $e"!%!% dan fa%t!""esi%! lainna+
Pada e$e"i%saan 6si% su%a" dite$u%an%elainan an) sesi6% %e8uali (i%a didaat%an"i'aat ena%it an) $en(adi fa%t!" "esi%!disliide$ia+
#elainan $un)%in didaat%an &ila suda* te"(adi%!$li%asi le&i* lan(ut see"ti ena%it (antun)
%!"!ne"+
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Pe$e"i%saan La&!"at!"iu$
Pe$e"i%saan an) dila%u%an adala*e$e"i%saan %ada" %!leste"!l t!tal
%!leste"!l LDL %!leste"!l DL dant"i)lise"id
#ada" LDL daat dila%u%an se8a"a
lan)sun) atau $en))una%an "u$usF"iede'aid (i%a didaat%an %ada"t"i)lise"ida < =00$)>d
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Penatalaksanaan
1+ tatala%sana n!n fa"$a%!l!)is
Nut"isi $edis
Pada asien den)an %ada" %!lest"!l t!tal
atau %!lest"!l LDL tin))i $a%a e"ludi%u"an)i asuan le$a% t!tal dan le$a% (enu* se"ta $enin)%atan asuan le$a%tida% (enu* "antai tun))al dan )anda+ Pada
asien den)an %ada" t"i)lise"ida tin))i$a%a di%u"an)i asuan %a"&!*id"at al8!*!ldan le$a%+ 5isa $en))una%an te$e+
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A%ti6tas 6si%
Da"i &e&e"aa enelitian te"&u%ti &a*'aa%ti6tas 6si% an) te"atu" daat
$enin)%at%an %ada" %!lest"!l DL dan a!A1dan $enu"un%an %ada" %!lest"!l LDL dan%!lest"!l t"i)lide"ida $enin)%at%ansensiti7itas insulin $e$e"&ai%i t!le"ansi
)lu%!sa $enin)%at%an %e&u)a"an se"ta$enu"un%an &e"at &adan+ 5e"*enti&e"a%ti7itas daat $enu"un%an %ada" %!lest"!lDL dala$ &e&e"aa &ulan+
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Ta")et enu"unan %!leste"!lLDL
Ta")et enu"unan %!leste"!l LDLdi%ate)!"i%an se&a)ai &e"i%ut?
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Tatala%sana "esi%! tin))i
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Tatala%sana "esi%! sedan)
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Tatala%sana "esi%! "enda*
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Penatala%sanaan se8a"au$u$ Pila" uta$a en)el!laan disliide$ia
adala* ? $!di6%asi diet lati*an (as$anise"ta en)el!laan &e"at &adan+ te"ai
diet $e$ili%i tu(uan untu% $enu"un%an"esi%! P#V den)an $en)u"an)i asuanle$a% (enu* dan %!leste"!l se"ta$en)e$&ali%an %esi$&an)an %al!"i
se%ali)us $e$e"&ai%i nut"isi+
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Tatala%sana fa"$a%!l!)is
Pen)!&atan fa"$a%!l!)i dila%u%an &ila te"(adi%e)a)alan den)an en)!&atan n!n4fa"$a%!l!)is+
O&at lini e"ta$a an) dan(u"%an !le* N9EP4ATPIII adala* HMG-CoA reductase inhibitor
%ada" t"i)lise"id @=00$)>dl en)!&atandi$ulai den)an )!l!n)an asa$ 6&"at untu%$enu"un%an t"i)lise"id+
na$un %ada" %!leste"!l LDL &elu$ $en8aaisasa"an $a%a HMG-CoA reductase inhibitor a%andi%!$&inasi%an den)an asa$ 6&"at+
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Pe$antauan "!6l liid dila%u%an setia $in))u+ 5ila ta")et suda* te"8aaie$antauan dilan(uta%an setia =4
&ulan+
5ila setela* $in))u te"ai ta")et
&elu$ te"8aai intensif%an>nai%%and!sis statin atau %!$&inasi den)an an)lain+
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De"i7at en)*a$&at M;9!A Redu%tase
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Si$7astatin -9*!leBin Et*i8!l Les7atinLiin!"e$ Me"si7as N!"$!fat
L!7astatin -9*!l7astin L!7a8!l Li!7as
Justin P"a7astatin -9*!lesa" ;"a7astin
#!les%!l
Flu7astatin -Les8!l At!"7astatin -T"u7a, Stat!" Liit!"
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GOLONGAN SEKUESTRAN ASAMEMPEDU
#!lesti"a$in
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GOLONGAN OBAT ASAM NIKOTINAT
A8ii$!B -Ol&eta$
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DISLIPIDEMIA PADA #EADAAN #CSCS
1+ Disliide$ia ada Dia&etes Mellitus
2+ Disliide$ia ada Sind"!$a Meta&!li%
3+ Disliide$ia ada *ie"tensi
=+ Disliide$ia ada )a)al )in(al
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Komlikasi
Aa&ila disliide$ia tida% se)e"a diatasi$a%a daat te"(adi &e"&a)ai $a8a$%!$li%asi anta"a lain at*e"!s%le"!sis
ena%it (antun) %!"!"ne" ena%itse"e&"!7as%ula" see"ti st"!%e %elainane$&ulu* da"a* tu&u* lainna danaan%"eatitis a%ut+
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